A non-canonical mismatch repair pathway in prokaryotes

A non-canonical mismatch repair pathway in prokaryotes

Despite the importance of mismatch repair for genome stability, many Archaea and almost all Actinobacteria lack MutS and MutL proteins. Here the authors, usingMycobacterium smegmatisas a model, report that NucS/EndoMS endonuclease acts in a distinct mismatch repair pathway.

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Detalles Bibliográficos
Autores principales: A. Castañeda-García, A. I. Prieto, J. Rodríguez-Beltrán, N. Alonso, D. Cantillon, C. Costas, L. Pérez-Lago, E. D. Zegeye, M. Herranz, P. Plociński, T. Tonjum, D. García de Viedma, M. Paget, S. J. Waddell, A. M. Rojas, A. J. Doherty, J. Blázquez
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/fbb1cf5e25104952a827c5274205d0f7
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Descripción
Sumario:Despite the importance of mismatch repair for genome stability, many Archaea and almost all Actinobacteria lack MutS and MutL proteins. Here the authors, usingMycobacterium smegmatisas a model, report that NucS/EndoMS endonuclease acts in a distinct mismatch repair pathway.

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