Resolution of persistent corneal erosion after administration of topical rebamipide

Tomoyuki Kashima,1,2 Hideo Akiyama,1 Fumihide Miura,2 Shoji Kishi11Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan; 2Department of Ophthalmology, Saku Central Hospital, Saku, JapanAbstract: Rebamipide is an antiulcer agent used to treat gastric ulcer and gastritis....

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Autores principales:	Kashima T, Akiyama H, Miura F, Kishi S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fbb23cd5690545428c52cae7c7f8a7a1
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spelling	oai:doaj.org-article:fbb23cd5690545428c52cae7c7f8a7a12021-12-02T01:26:35ZResolution of persistent corneal erosion after administration of topical rebamipide1177-54671177-5483https://doaj.org/article/fbb23cd5690545428c52cae7c7f8a7a12012-08-01T00:00:00Zhttp://www.dovepress.com/resolution-of-persistent-corneal-erosion-after-administration-of-topic-a10851https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Tomoyuki Kashima,1,2 Hideo Akiyama,1 Fumihide Miura,2 Shoji Kishi11Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan; 2Department of Ophthalmology, Saku Central Hospital, Saku, JapanAbstract: Rebamipide is an antiulcer agent used to treat gastric ulcer and gastritis. Biological effects of rebamipide include cytoprotection, wound healing, and anti-inflammatory properties that are known to be universal for a variety of tissues in addition to gastrointestinal mucosa. The therapeutic effects of rebamipide eye drops are due to its ability to increase corneal and conjunctival mucin-like substances and improve corneal and conjunctival injury in vivo. In this paper, we report a case of Sj&ouml;gren&#39;s syndrome with complete disappearance of corneal erosion after administration of rebamipide eye drops. This was observed even though corneal erosion had not improved for 6 months after punctal occlusion surgery. The patient was a 33-year-old female, diagnosed with Sj&ouml;gren&#39;s syndrome by a salivary gland biopsy. The corneal and conjunctival surfaces were filled with dense erosions, which did not improve with topical drugs. Punctal plugs were applied several times; however, the plugs were repeatedly shed. All four puncta of both eyelids were surgically occluded, and both corneal and conjunctival erosion was clearly improved. However, the erosion in the inferior cornea of both eyes had not improved for 6 months after surgery. We used the newly approved topical rebamipide for treatment of this patient. The corneal erosion gradually improved and completely disappeared 4 weeks after administration of the drug. Dry eye sensation disappeared at the same time. Both membrane-associated mucin and secreted mucin in the ocular surface are thought to be essential for maintenance of the tear film. Induction of mucin from ocular surface epithelium could be an effective treatment in cases of dry eye caused by mucin deficiency. Through its various mechanisms, rebamipide improves ocular surface conditions. To our knowledge, this is the first clinical case report using rebamipide ophthalmic solution. This drug may provide a novel approach to treat drying diseases of the eye.Keywords: Sj&ouml;gren&#39;s syndrome, dry eye, corneal erosion, rebamipide, Mucosta, mucinKashima TAkiyama HMiura FKishi SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1403-1406 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kashima T Akiyama H Miura F Kishi S Resolution of persistent corneal erosion after administration of topical rebamipide
description	Tomoyuki Kashima,1,2 Hideo Akiyama,1 Fumihide Miura,2 Shoji Kishi11Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan; 2Department of Ophthalmology, Saku Central Hospital, Saku, JapanAbstract: Rebamipide is an antiulcer agent used to treat gastric ulcer and gastritis. Biological effects of rebamipide include cytoprotection, wound healing, and anti-inflammatory properties that are known to be universal for a variety of tissues in addition to gastrointestinal mucosa. The therapeutic effects of rebamipide eye drops are due to its ability to increase corneal and conjunctival mucin-like substances and improve corneal and conjunctival injury in vivo. In this paper, we report a case of Sj&ouml;gren&#39;s syndrome with complete disappearance of corneal erosion after administration of rebamipide eye drops. This was observed even though corneal erosion had not improved for 6 months after punctal occlusion surgery. The patient was a 33-year-old female, diagnosed with Sj&ouml;gren&#39;s syndrome by a salivary gland biopsy. The corneal and conjunctival surfaces were filled with dense erosions, which did not improve with topical drugs. Punctal plugs were applied several times; however, the plugs were repeatedly shed. All four puncta of both eyelids were surgically occluded, and both corneal and conjunctival erosion was clearly improved. However, the erosion in the inferior cornea of both eyes had not improved for 6 months after surgery. We used the newly approved topical rebamipide for treatment of this patient. The corneal erosion gradually improved and completely disappeared 4 weeks after administration of the drug. Dry eye sensation disappeared at the same time. Both membrane-associated mucin and secreted mucin in the ocular surface are thought to be essential for maintenance of the tear film. Induction of mucin from ocular surface epithelium could be an effective treatment in cases of dry eye caused by mucin deficiency. Through its various mechanisms, rebamipide improves ocular surface conditions. To our knowledge, this is the first clinical case report using rebamipide ophthalmic solution. This drug may provide a novel approach to treat drying diseases of the eye.Keywords: Sj&ouml;gren&#39;s syndrome, dry eye, corneal erosion, rebamipide, Mucosta, mucin
format	article
author	Kashima T Akiyama H Miura F Kishi S
author_facet	Kashima T Akiyama H Miura F Kishi S
author_sort	Kashima T
title	Resolution of persistent corneal erosion after administration of topical rebamipide
title_short	Resolution of persistent corneal erosion after administration of topical rebamipide
title_full	Resolution of persistent corneal erosion after administration of topical rebamipide
title_fullStr	Resolution of persistent corneal erosion after administration of topical rebamipide
title_full_unstemmed	Resolution of persistent corneal erosion after administration of topical rebamipide
title_sort	resolution of persistent corneal erosion after administration of topical rebamipide
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/fbb23cd5690545428c52cae7c7f8a7a1
work_keys_str_mv	AT kashimat resolutionofpersistentcornealerosionafteradministrationoftopicalrebamipide AT akiyamah resolutionofpersistentcornealerosionafteradministrationoftopicalrebamipide AT miuraf resolutionofpersistentcornealerosionafteradministrationoftopicalrebamipide AT kishis resolutionofpersistentcornealerosionafteradministrationoftopicalrebamipide
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Resolution of persistent corneal erosion after administration of topical rebamipide

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