Structural insight on assembly-line catalysis in terpene biosynthesis

Substrate channeling can improve biosynthetic efficiency and has been implicated in the reactions of fusicoccadiene synthase. Here, the authors analyze this bifunctional enzyme complex by cryoEM, cross-linking MS and integrative modeling, providing structural insights into how substrate channeling i...

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Auteurs principaux:	Jacque L. Faylo, Trevor van Eeuwen, Hee Jong Kim, Jose J. Gorbea Colón, Benjamin A. Garcia, Kenji Murakami, David W. Christianson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/fbb2f4b36b8d4e3eaddd473f28e72330
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spelling	oai:doaj.org-article:fbb2f4b36b8d4e3eaddd473f28e723302021-12-02T17:52:09ZStructural insight on assembly-line catalysis in terpene biosynthesis10.1038/s41467-021-23589-92041-1723https://doaj.org/article/fbb2f4b36b8d4e3eaddd473f28e723302021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23589-9https://doaj.org/toc/2041-1723Substrate channeling can improve biosynthetic efficiency and has been implicated in the reactions of fusicoccadiene synthase. Here, the authors analyze this bifunctional enzyme complex by cryoEM, cross-linking MS and integrative modeling, providing structural insights into how substrate channeling is achieved.Jacque L. FayloTrevor van EeuwenHee Jong KimJose J. Gorbea ColónBenjamin A. GarciaKenji MurakamiDavid W. ChristiansonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacque L. Faylo Trevor van Eeuwen Hee Jong Kim Jose J. Gorbea Colón Benjamin A. Garcia Kenji Murakami David W. Christianson Structural insight on assembly-line catalysis in terpene biosynthesis
description	Substrate channeling can improve biosynthetic efficiency and has been implicated in the reactions of fusicoccadiene synthase. Here, the authors analyze this bifunctional enzyme complex by cryoEM, cross-linking MS and integrative modeling, providing structural insights into how substrate channeling is achieved.
format	article
author	Jacque L. Faylo Trevor van Eeuwen Hee Jong Kim Jose J. Gorbea Colón Benjamin A. Garcia Kenji Murakami David W. Christianson
author_facet	Jacque L. Faylo Trevor van Eeuwen Hee Jong Kim Jose J. Gorbea Colón Benjamin A. Garcia Kenji Murakami David W. Christianson
author_sort	Jacque L. Faylo
title	Structural insight on assembly-line catalysis in terpene biosynthesis
title_short	Structural insight on assembly-line catalysis in terpene biosynthesis
title_full	Structural insight on assembly-line catalysis in terpene biosynthesis
title_fullStr	Structural insight on assembly-line catalysis in terpene biosynthesis
title_full_unstemmed	Structural insight on assembly-line catalysis in terpene biosynthesis
title_sort	structural insight on assembly-line catalysis in terpene biosynthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbb2f4b36b8d4e3eaddd473f28e72330
work_keys_str_mv	AT jacquelfaylo structuralinsightonassemblylinecatalysisinterpenebiosynthesis AT trevorvaneeuwen structuralinsightonassemblylinecatalysisinterpenebiosynthesis AT heejongkim structuralinsightonassemblylinecatalysisinterpenebiosynthesis AT josejgorbeacolon structuralinsightonassemblylinecatalysisinterpenebiosynthesis AT benjaminagarcia structuralinsightonassemblylinecatalysisinterpenebiosynthesis AT kenjimurakami structuralinsightonassemblylinecatalysisinterpenebiosynthesis AT davidwchristianson structuralinsightonassemblylinecatalysisinterpenebiosynthesis
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Structural insight on assembly-line catalysis in terpene biosynthesis

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