Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes assembling complex natural products. Here, the structures of a Thermobifida fusca NRPS condensation domain bound to the substrate-bearing peptidyl carrier protein (PCP) domain provide insight into the mechanisms of substrate selecti...

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Autores principales:	Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbb66a8fa3204b6a841066cc1c1e62db
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spelling	oai:doaj.org-article:fbb66a8fa3204b6a841066cc1c1e62db2021-12-02T16:51:30ZStructures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity10.1038/s41467-021-22623-02041-1723https://doaj.org/article/fbb66a8fa3204b6a841066cc1c1e62db2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22623-0https://doaj.org/toc/2041-1723Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes assembling complex natural products. Here, the structures of a Thermobifida fusca NRPS condensation domain bound to the substrate-bearing peptidyl carrier protein (PCP) domain provide insight into the mechanisms of substrate selectivity and engagement within the catalytic pocket.Thierry IzoréY. T. Candace HoJoe A. KaczmarskiAthina GavriilidouKa Ho ChowDavid L. SteerRobert J. A. GoodeRalf B. SchittenhelmJulien TailhadesManuela TosinGregory L. ChallisElizabeth H. KrenskeNadine ZiemertColin J. JacksonMax J. CryleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thierry Izoré Y. T. Candace Ho Joe A. Kaczmarski Athina Gavriilidou Ka Ho Chow David L. Steer Robert J. A. Goode Ralf B. Schittenhelm Julien Tailhades Manuela Tosin Gregory L. Challis Elizabeth H. Krenske Nadine Ziemert Colin J. Jackson Max J. Cryle Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
description	Non-ribosomal peptide synthetases (NRPSs) are multi-modular enzymes assembling complex natural products. Here, the structures of a Thermobifida fusca NRPS condensation domain bound to the substrate-bearing peptidyl carrier protein (PCP) domain provide insight into the mechanisms of substrate selectivity and engagement within the catalytic pocket.
format	article
author	Thierry Izoré Y. T. Candace Ho Joe A. Kaczmarski Athina Gavriilidou Ka Ho Chow David L. Steer Robert J. A. Goode Ralf B. Schittenhelm Julien Tailhades Manuela Tosin Gregory L. Challis Elizabeth H. Krenske Nadine Ziemert Colin J. Jackson Max J. Cryle
author_facet	Thierry Izoré Y. T. Candace Ho Joe A. Kaczmarski Athina Gavriilidou Ka Ho Chow David L. Steer Robert J. A. Goode Ralf B. Schittenhelm Julien Tailhades Manuela Tosin Gregory L. Challis Elizabeth H. Krenske Nadine Ziemert Colin J. Jackson Max J. Cryle
author_sort	Thierry Izoré
title	Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
title_short	Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
title_full	Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
title_fullStr	Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
title_full_unstemmed	Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
title_sort	structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbb66a8fa3204b6a841066cc1c1e62db
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Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

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