LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated inflammation and hyperglycemia in T1DM mouse mode...

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Autores principales: Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Noelia García Rodríguez, Irene de Gracia Herrera Gómez, Esther Fuente-Martin, Livia López-Noriega, José Manuel Mellado-Gil, Silvana-Yanina Romero-Zerbo, Mathurin Baquié, Christian Claude Lachaud, Katja Stifter, German Perdomo, Marco Bugliani, Vincenzo De Tata, Domenico Bosco, Geraldine Parnaud, David Pozo, Abdelkrim Hmadcha, Javier P. Florido, Miguel G. Toscano, Peter de Haan, Kristina Schoonjans, Luis Sánchez Palazón, Piero Marchetti, Reinhold Schirmbeck, Alejandro Martín-Montalvo, Paolo Meda, Bernat Soria, Francisco-Javier Bermúdez-Silva, Luc St-Onge, Benoit R. Gauthier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/fbb9d971aff1451c95b83f3e8763290c
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spelling oai:doaj.org-article:fbb9d971aff1451c95b83f3e8763290c2021-12-02T17:33:16ZLRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus10.1038/s41467-018-03943-02041-1723https://doaj.org/article/fbb9d971aff1451c95b83f3e8763290c2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03943-0https://doaj.org/toc/2041-1723Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated inflammation and hyperglycemia in T1DM mouse models.Nadia Cobo-VuilleumierPetra I. LorenzoNoelia García RodríguezIrene de Gracia Herrera GómezEsther Fuente-MartinLivia López-NoriegaJosé Manuel Mellado-GilSilvana-Yanina Romero-ZerboMathurin BaquiéChristian Claude LachaudKatja StifterGerman PerdomoMarco BuglianiVincenzo De TataDomenico BoscoGeraldine ParnaudDavid PozoAbdelkrim HmadchaJavier P. FloridoMiguel G. ToscanoPeter de HaanKristina SchoonjansLuis Sánchez PalazónPiero MarchettiReinhold SchirmbeckAlejandro Martín-MontalvoPaolo MedaBernat SoriaFrancisco-Javier Bermúdez-SilvaLuc St-OngeBenoit R. GauthierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nadia Cobo-Vuilleumier
Petra I. Lorenzo
Noelia García Rodríguez
Irene de Gracia Herrera Gómez
Esther Fuente-Martin
Livia López-Noriega
José Manuel Mellado-Gil
Silvana-Yanina Romero-Zerbo
Mathurin Baquié
Christian Claude Lachaud
Katja Stifter
German Perdomo
Marco Bugliani
Vincenzo De Tata
Domenico Bosco
Geraldine Parnaud
David Pozo
Abdelkrim Hmadcha
Javier P. Florido
Miguel G. Toscano
Peter de Haan
Kristina Schoonjans
Luis Sánchez Palazón
Piero Marchetti
Reinhold Schirmbeck
Alejandro Martín-Montalvo
Paolo Meda
Bernat Soria
Francisco-Javier Bermúdez-Silva
Luc St-Onge
Benoit R. Gauthier
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
description Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated inflammation and hyperglycemia in T1DM mouse models.
format article
author Nadia Cobo-Vuilleumier
Petra I. Lorenzo
Noelia García Rodríguez
Irene de Gracia Herrera Gómez
Esther Fuente-Martin
Livia López-Noriega
José Manuel Mellado-Gil
Silvana-Yanina Romero-Zerbo
Mathurin Baquié
Christian Claude Lachaud
Katja Stifter
German Perdomo
Marco Bugliani
Vincenzo De Tata
Domenico Bosco
Geraldine Parnaud
David Pozo
Abdelkrim Hmadcha
Javier P. Florido
Miguel G. Toscano
Peter de Haan
Kristina Schoonjans
Luis Sánchez Palazón
Piero Marchetti
Reinhold Schirmbeck
Alejandro Martín-Montalvo
Paolo Meda
Bernat Soria
Francisco-Javier Bermúdez-Silva
Luc St-Onge
Benoit R. Gauthier
author_facet Nadia Cobo-Vuilleumier
Petra I. Lorenzo
Noelia García Rodríguez
Irene de Gracia Herrera Gómez
Esther Fuente-Martin
Livia López-Noriega
José Manuel Mellado-Gil
Silvana-Yanina Romero-Zerbo
Mathurin Baquié
Christian Claude Lachaud
Katja Stifter
German Perdomo
Marco Bugliani
Vincenzo De Tata
Domenico Bosco
Geraldine Parnaud
David Pozo
Abdelkrim Hmadcha
Javier P. Florido
Miguel G. Toscano
Peter de Haan
Kristina Schoonjans
Luis Sánchez Palazón
Piero Marchetti
Reinhold Schirmbeck
Alejandro Martín-Montalvo
Paolo Meda
Bernat Soria
Francisco-Javier Bermúdez-Silva
Luc St-Onge
Benoit R. Gauthier
author_sort Nadia Cobo-Vuilleumier
title LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
title_short LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
title_full LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
title_fullStr LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
title_full_unstemmed LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
title_sort lrh-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/fbb9d971aff1451c95b83f3e8763290c
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