Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

The GntR superfamily is one of the largest families of transcription factors in prokaryotes. Here the authors combine biophysical analysis and structural biology to dissect the mechanism by which NanR — a GntR-family regulator — binds to its promoter to repress the transcription of genes necessary f...

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Autores principales:	Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar, David M. Wood, Amy Henrickson, Emre Brookes, Rachel A. North, James M. Murphy, Rosmarie Friemann, Michael D. W. Griffin, Georg Ramm, Borries Demeler, Renwick C. J. Dobson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbbaf67cd57e43b9861716dfe16d3c75
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spelling	oai:doaj.org-article:fbbaf67cd57e43b9861716dfe16d3c752021-12-02T14:23:17ZMechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism10.1038/s41467-021-22253-62041-1723https://doaj.org/article/fbbaf67cd57e43b9861716dfe16d3c752021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22253-6https://doaj.org/toc/2041-1723The GntR superfamily is one of the largest families of transcription factors in prokaryotes. Here the authors combine biophysical analysis and structural biology to dissect the mechanism by which NanR — a GntR-family regulator — binds to its promoter to repress the transcription of genes necessary for sialic acid metabolism.Christopher R. HorneHariprasad VenugopalSantosh PanjikarDavid M. WoodAmy HenricksonEmre BrookesRachel A. NorthJames M. MurphyRosmarie FriemannMichael D. W. GriffinGeorg RammBorries DemelerRenwick C. J. DobsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher R. Horne Hariprasad Venugopal Santosh Panjikar David M. Wood Amy Henrickson Emre Brookes Rachel A. North James M. Murphy Rosmarie Friemann Michael D. W. Griffin Georg Ramm Borries Demeler Renwick C. J. Dobson Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
description	The GntR superfamily is one of the largest families of transcription factors in prokaryotes. Here the authors combine biophysical analysis and structural biology to dissect the mechanism by which NanR — a GntR-family regulator — binds to its promoter to repress the transcription of genes necessary for sialic acid metabolism.
format	article
author	Christopher R. Horne Hariprasad Venugopal Santosh Panjikar David M. Wood Amy Henrickson Emre Brookes Rachel A. North James M. Murphy Rosmarie Friemann Michael D. W. Griffin Georg Ramm Borries Demeler Renwick C. J. Dobson
author_facet	Christopher R. Horne Hariprasad Venugopal Santosh Panjikar David M. Wood Amy Henrickson Emre Brookes Rachel A. North James M. Murphy Rosmarie Friemann Michael D. W. Griffin Georg Ramm Borries Demeler Renwick C. J. Dobson
author_sort	Christopher R. Horne
title	Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
title_short	Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
title_full	Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
title_fullStr	Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
title_full_unstemmed	Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
title_sort	mechanism of nanr gene repression and allosteric induction of bacterial sialic acid metabolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbbaf67cd57e43b9861716dfe16d3c75
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Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

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