The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders

Brandon H Mai, Liang-Jun YanDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USAAbstract: The increased consumption of fructose in the average diet through sweeteners such as high-fructose corn syrup (HFCS)...

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Autores principales:	Mai BH, Yan LJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	fructose liver metabolic syndrome non-alcoholic fatty liver disease non-alcoholic steatohepatitis Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/fbbb01c08f0f4eedb42e4ea3a2e15769
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spelling	oai:doaj.org-article:fbbb01c08f0f4eedb42e4ea3a2e157692021-12-02T09:08:50ZThe negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders1178-7007https://doaj.org/article/fbbb01c08f0f4eedb42e4ea3a2e157692019-05-01T00:00:00Zhttps://www.dovepress.com/the-negative-and-detrimental-effects-of-high-fructose-on-the-liver-wit-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Brandon H Mai, Liang-Jun YanDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USAAbstract: The increased consumption of fructose in the average diet through sweeteners such as high-fructose corn syrup (HFCS) and sucrose has resulted in negative outcomes in society through producing a considerable economic and medical burden on our healthcare system. Ingestion of fructose chronically has contributed to multiple health consequences, such as insulin resistance, obesity, liver disorders, and diabetes. Fructose metabolism starts with fructose phosphorylation by fructose kinase in the liver, and this process is not feedback regulated. Therefore, ingestion of high fructose can deplete ATP, increase uric acid production, and increase nucleotide turnover. This review focuses the discussion on the hepatic manifestations of high fructose-implicated liver metabolic disorders such as insulin resistance, obesity due to enhanced lipogenesis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and type 2 diabetes. The detrimental effects of high fructose on the liver, contributed potentially by microbiome and leptin, were also discussed. The authors believe that, together with diet management, further studies focusing on disrupting or blocking fructose metabolism in the liver may help with designing novel strategies for prevention and treatment of fructose-induced chronic liver metabolic diseases.Keywords: fructose, liver, metabolic syndrome, non-alcoholic fatty liver disease, non-alcoholic steatohepatitisMai BHYan LJDove Medical Pressarticlefructoselivermetabolic syndromenon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 821-826 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	fructose liver metabolic syndrome non-alcoholic fatty liver disease non-alcoholic steatohepatitis Specialties of internal medicine RC581-951
spellingShingle	fructose liver metabolic syndrome non-alcoholic fatty liver disease non-alcoholic steatohepatitis Specialties of internal medicine RC581-951 Mai BH Yan LJ The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
description	Brandon H Mai, Liang-Jun YanDepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USAAbstract: The increased consumption of fructose in the average diet through sweeteners such as high-fructose corn syrup (HFCS) and sucrose has resulted in negative outcomes in society through producing a considerable economic and medical burden on our healthcare system. Ingestion of fructose chronically has contributed to multiple health consequences, such as insulin resistance, obesity, liver disorders, and diabetes. Fructose metabolism starts with fructose phosphorylation by fructose kinase in the liver, and this process is not feedback regulated. Therefore, ingestion of high fructose can deplete ATP, increase uric acid production, and increase nucleotide turnover. This review focuses the discussion on the hepatic manifestations of high fructose-implicated liver metabolic disorders such as insulin resistance, obesity due to enhanced lipogenesis, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and type 2 diabetes. The detrimental effects of high fructose on the liver, contributed potentially by microbiome and leptin, were also discussed. The authors believe that, together with diet management, further studies focusing on disrupting or blocking fructose metabolism in the liver may help with designing novel strategies for prevention and treatment of fructose-induced chronic liver metabolic diseases.Keywords: fructose, liver, metabolic syndrome, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis
format	article
author	Mai BH Yan LJ
author_facet	Mai BH Yan LJ
author_sort	Mai BH
title	The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
title_short	The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
title_full	The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
title_fullStr	The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
title_full_unstemmed	The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
title_sort	negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/fbbb01c08f0f4eedb42e4ea3a2e15769
work_keys_str_mv	AT maibh thenegativeanddetrimentaleffectsofhighfructoseontheliverwithspecialreferencetometabolicdisorders AT yanlj thenegativeanddetrimentaleffectsofhighfructoseontheliverwithspecialreferencetometabolicdisorders AT maibh negativeanddetrimentaleffectsofhighfructoseontheliverwithspecialreferencetometabolicdisorders AT yanlj negativeanddetrimentaleffectsofhighfructoseontheliverwithspecialreferencetometabolicdisorders
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The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders

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