DNA methylation signatures in peripheral blood strongly predict all-cause mortality

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

DNA methylation is modulated by environmental factors and has a role in many complex diseases. Here, the authors find that methylation at specific DNA sites is associated with all-cause mortality, and a methylation-based risk score may be informative for risk assessment and stratification.

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Autores principales: Yan Zhang, Rory Wilson, Jonathan Heiss, Lutz P. Breitling, Kai-Uwe Saum, Ben Schöttker, Bernd Holleczek, Melanie Waldenberger, Annette Peters, Hermann Brenner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/fbbc5b46bcdc4ee5858ae5ff919a63da
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spelling oai:doaj.org-article:fbbc5b46bcdc4ee5858ae5ff919a63da2021-12-02T14:42:44ZDNA methylation signatures in peripheral blood strongly predict all-cause mortality10.1038/ncomms146172041-1723https://doaj.org/article/fbbc5b46bcdc4ee5858ae5ff919a63da2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14617https://doaj.org/toc/2041-1723DNA methylation is modulated by environmental factors and has a role in many complex diseases. Here, the authors find that methylation at specific DNA sites is associated with all-cause mortality, and a methylation-based risk score may be informative for risk assessment and stratification.Yan ZhangRory WilsonJonathan HeissLutz P. BreitlingKai-Uwe SaumBen SchöttkerBernd HolleczekMelanie WaldenbergerAnnette PetersHermann BrennerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yan Zhang
Rory Wilson
Jonathan Heiss
Lutz P. Breitling
Kai-Uwe Saum
Ben Schöttker
Bernd Holleczek
Melanie Waldenberger
Annette Peters
Hermann Brenner
DNA methylation signatures in peripheral blood strongly predict all-cause mortality
description DNA methylation is modulated by environmental factors and has a role in many complex diseases. Here, the authors find that methylation at specific DNA sites is associated with all-cause mortality, and a methylation-based risk score may be informative for risk assessment and stratification.
format article
author Yan Zhang
Rory Wilson
Jonathan Heiss
Lutz P. Breitling
Kai-Uwe Saum
Ben Schöttker
Bernd Holleczek
Melanie Waldenberger
Annette Peters
Hermann Brenner
author_facet Yan Zhang
Rory Wilson
Jonathan Heiss
Lutz P. Breitling
Kai-Uwe Saum
Ben Schöttker
Bernd Holleczek
Melanie Waldenberger
Annette Peters
Hermann Brenner
author_sort Yan Zhang
title DNA methylation signatures in peripheral blood strongly predict all-cause mortality
title_short DNA methylation signatures in peripheral blood strongly predict all-cause mortality
title_full DNA methylation signatures in peripheral blood strongly predict all-cause mortality
title_fullStr DNA methylation signatures in peripheral blood strongly predict all-cause mortality
title_full_unstemmed DNA methylation signatures in peripheral blood strongly predict all-cause mortality
title_sort dna methylation signatures in peripheral blood strongly predict all-cause mortality
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/fbbc5b46bcdc4ee5858ae5ff919a63da
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AT rorywilson dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
AT jonathanheiss dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
AT lutzpbreitling dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
AT kaiuwesaum dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
AT benschottker dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
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AT melaniewaldenberger dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
AT annettepeters dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
AT hermannbrenner dnamethylationsignaturesinperipheralbloodstronglypredictallcausemortality
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