A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is characterised by progressive pulmonary vascular remodelling. Here, Arnold et al. develop a therapeutic antibody targeting osteoprotegerin and find it attenuates pulmonary vascular remodelling in multiple rodent models of PAH, alone or in combination with stan...

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Autores principales:	Nadine D. Arnold, Josephine A. Pickworth, Laura E. West, Sarah Dawson, Joana A. Carvalho, Helen Casbolt, Adam T. Braithwaite, James Iremonger, Lewis Renshall, Volker Germaschewski, Matthew McCourt, Philip Bland-Ward, Hager Kowash, Abdul G. Hameed, Alexander M. K. Rothman, Maria G. Frid, A. A. Roger Thompson, Holly R. Evans, Mark Southwood, Nicholas W. Morrell, David C. Crossman, Moira K. B. Whyte, Kurt R. Stenmark, Christopher M. Newman, David G. Kiely, Sheila E. Francis, Allan Lawrie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbbe9cf6fb44471db21ebf04ce2094b6
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spelling	oai:doaj.org-article:fbbe9cf6fb44471db21ebf04ce2094b62021-12-02T17:32:56ZA therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension10.1038/s41467-019-13139-92041-1723https://doaj.org/article/fbbe9cf6fb44471db21ebf04ce2094b62019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13139-9https://doaj.org/toc/2041-1723Pulmonary arterial hypertension (PAH) is characterised by progressive pulmonary vascular remodelling. Here, Arnold et al. develop a therapeutic antibody targeting osteoprotegerin and find it attenuates pulmonary vascular remodelling in multiple rodent models of PAH, alone or in combination with standard of care vasodilator therapy.Nadine D. ArnoldJosephine A. PickworthLaura E. WestSarah DawsonJoana A. CarvalhoHelen CasboltAdam T. BraithwaiteJames IremongerLewis RenshallVolker GermaschewskiMatthew McCourtPhilip Bland-WardHager KowashAbdul G. HameedAlexander M. K. RothmanMaria G. FridA. A. Roger ThompsonHolly R. EvansMark SouthwoodNicholas W. MorrellDavid C. CrossmanMoira K. B. WhyteKurt R. StenmarkChristopher M. NewmanDavid G. KielySheila E. FrancisAllan LawrieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadine D. Arnold Josephine A. Pickworth Laura E. West Sarah Dawson Joana A. Carvalho Helen Casbolt Adam T. Braithwaite James Iremonger Lewis Renshall Volker Germaschewski Matthew McCourt Philip Bland-Ward Hager Kowash Abdul G. Hameed Alexander M. K. Rothman Maria G. Frid A. A. Roger Thompson Holly R. Evans Mark Southwood Nicholas W. Morrell David C. Crossman Moira K. B. Whyte Kurt R. Stenmark Christopher M. Newman David G. Kiely Sheila E. Francis Allan Lawrie A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
description	Pulmonary arterial hypertension (PAH) is characterised by progressive pulmonary vascular remodelling. Here, Arnold et al. develop a therapeutic antibody targeting osteoprotegerin and find it attenuates pulmonary vascular remodelling in multiple rodent models of PAH, alone or in combination with standard of care vasodilator therapy.
format	article
author	Nadine D. Arnold Josephine A. Pickworth Laura E. West Sarah Dawson Joana A. Carvalho Helen Casbolt Adam T. Braithwaite James Iremonger Lewis Renshall Volker Germaschewski Matthew McCourt Philip Bland-Ward Hager Kowash Abdul G. Hameed Alexander M. K. Rothman Maria G. Frid A. A. Roger Thompson Holly R. Evans Mark Southwood Nicholas W. Morrell David C. Crossman Moira K. B. Whyte Kurt R. Stenmark Christopher M. Newman David G. Kiely Sheila E. Francis Allan Lawrie
author_facet	Nadine D. Arnold Josephine A. Pickworth Laura E. West Sarah Dawson Joana A. Carvalho Helen Casbolt Adam T. Braithwaite James Iremonger Lewis Renshall Volker Germaschewski Matthew McCourt Philip Bland-Ward Hager Kowash Abdul G. Hameed Alexander M. K. Rothman Maria G. Frid A. A. Roger Thompson Holly R. Evans Mark Southwood Nicholas W. Morrell David C. Crossman Moira K. B. Whyte Kurt R. Stenmark Christopher M. Newman David G. Kiely Sheila E. Francis Allan Lawrie
author_sort	Nadine D. Arnold
title	A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
title_short	A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
title_full	A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
title_fullStr	A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
title_full_unstemmed	A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
title_sort	therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fbbe9cf6fb44471db21ebf04ce2094b6
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A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

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