Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City

Public health interventions such as social distancing and mask wearing decrease the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but it is unclear whether they decrease the viral load of infected patients and whether changes in viral load impact mortality from...

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Autores principales:	Michael J. Satlin, Jason Zucker, Benjamin R. Baer, Mangala Rajan, Nathaniel Hupert, Luis M. Schang, Laura C. Pinheiro, Yanhan Shen, Magdalena E. Sobieszczyk, Lars F. Westblade, Parag Goyal, Martin T. Wells, Jorge L. Sepulveda, Monika M. Safford
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbc094ab1f74405186cec95d63c22a53
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spelling	oai:doaj.org-article:fbc094ab1f74405186cec95d63c22a532021-11-25T06:19:31ZChanges in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City1932-6203https://doaj.org/article/fbc094ab1f74405186cec95d63c22a532021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604305/?tool=EBIhttps://doaj.org/toc/1932-6203Public health interventions such as social distancing and mask wearing decrease the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but it is unclear whether they decrease the viral load of infected patients and whether changes in viral load impact mortality from coronavirus disease 2019 (COVID-19). We evaluated 6923 patients with COVID-19 at six New York City hospitals from March 15-May 14, 2020, corresponding with the implementation of public health interventions in March. We assessed changes in cycle threshold (CT) values from reverse transcription-polymerase chain reaction tests and in-hospital mortality and modeled the impact of viral load on mortality. Mean CT values increased between March and May, with the proportion of patients with high viral load decreasing from 47.7% to 7.8%. In-hospital mortality increased from 14.9% in March to 28.4% in early April, and then decreased to 8.7% by May. Patients with high viral loads had increased mortality compared to those with low viral loads (adjusted odds ratio 2.34). If viral load had not declined, an estimated 69 additional deaths would have occurred (5.8% higher mortality). SARS-CoV-2 viral load steadily declined among hospitalized patients in the setting of public health interventions, and this correlated with decreases in mortality.Michael J. SatlinJason ZuckerBenjamin R. BaerMangala RajanNathaniel HupertLuis M. SchangLaura C. PinheiroYanhan ShenMagdalena E. SobieszczykLars F. WestbladeParag GoyalMartin T. WellsJorge L. SepulvedaMonika M. SaffordPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael J. Satlin Jason Zucker Benjamin R. Baer Mangala Rajan Nathaniel Hupert Luis M. Schang Laura C. Pinheiro Yanhan Shen Magdalena E. Sobieszczyk Lars F. Westblade Parag Goyal Martin T. Wells Jorge L. Sepulveda Monika M. Safford Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City
description	Public health interventions such as social distancing and mask wearing decrease the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but it is unclear whether they decrease the viral load of infected patients and whether changes in viral load impact mortality from coronavirus disease 2019 (COVID-19). We evaluated 6923 patients with COVID-19 at six New York City hospitals from March 15-May 14, 2020, corresponding with the implementation of public health interventions in March. We assessed changes in cycle threshold (CT) values from reverse transcription-polymerase chain reaction tests and in-hospital mortality and modeled the impact of viral load on mortality. Mean CT values increased between March and May, with the proportion of patients with high viral load decreasing from 47.7% to 7.8%. In-hospital mortality increased from 14.9% in March to 28.4% in early April, and then decreased to 8.7% by May. Patients with high viral loads had increased mortality compared to those with low viral loads (adjusted odds ratio 2.34). If viral load had not declined, an estimated 69 additional deaths would have occurred (5.8% higher mortality). SARS-CoV-2 viral load steadily declined among hospitalized patients in the setting of public health interventions, and this correlated with decreases in mortality.
format	article
author	Michael J. Satlin Jason Zucker Benjamin R. Baer Mangala Rajan Nathaniel Hupert Luis M. Schang Laura C. Pinheiro Yanhan Shen Magdalena E. Sobieszczyk Lars F. Westblade Parag Goyal Martin T. Wells Jorge L. Sepulveda Monika M. Safford
author_facet	Michael J. Satlin Jason Zucker Benjamin R. Baer Mangala Rajan Nathaniel Hupert Luis M. Schang Laura C. Pinheiro Yanhan Shen Magdalena E. Sobieszczyk Lars F. Westblade Parag Goyal Martin T. Wells Jorge L. Sepulveda Monika M. Safford
author_sort	Michael J. Satlin
title	Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City
title_short	Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City
title_full	Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City
title_fullStr	Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City
title_full_unstemmed	Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City
title_sort	changes in sars-cov-2 viral load and mortality during the initial wave of the pandemic in new york city
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fbc094ab1f74405186cec95d63c22a53
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Changes in SARS-CoV-2 viral load and mortality during the initial wave of the pandemic in New York City

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