Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis

The number of patients awaiting liver transplantation still widely exceeds the number of donated organs available. Patients receiving extended criteria donor (ECD) organs are especially prone to an aggravated ischemia reperfusion syndrome during liver transplantation leading to massive hemodynamic s...

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Autores principales:	Anna B. Roehl, Anne Andert, Karsten Junge, Ulf P. Neumann, Marc Hein, Felix Kork
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aprotinin liver transplantation human extended donor criteria Medicine R
Acceso en línea:	https://doaj.org/article/fbc14532e65341cf9220138f86f6227b
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spelling	oai:doaj.org-article:fbc14532e65341cf9220138f86f6227b2021-11-25T18:00:43ZEffect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis10.3390/jcm102252322077-0383https://doaj.org/article/fbc14532e65341cf9220138f86f6227b2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5232https://doaj.org/toc/2077-0383The number of patients awaiting liver transplantation still widely exceeds the number of donated organs available. Patients receiving extended criteria donor (ECD) organs are especially prone to an aggravated ischemia reperfusion syndrome during liver transplantation leading to massive hemodynamic stress and possible impairment in organ function. Previous studies have demonstrated aprotinin to ameliorate reperfusion injury and early graft survival. In this single center retrospective analysis of 84 propensity score matched patients out of 274 liver transplantation patients between 2010 and 2014 (OLT), we describe the association of aprotinin with postreperfusion syndrome (PRS), early allograft dysfunction (EAD: INR 1,6, AST/ALT > 2000 within 7–10 days) and recipient survival. The incidence of PRS (52.4% vs. 47.6%) and 30-day mortality did not differ (4.8 vs. 0%; <i>p</i> = 0.152) but patients treated with aprotinin suffered more often from EAD (64.3% vs. 40.5%, <i>p</i> = 0.029) compared to controls. Acceptable or poor (OR = 3.3, <i>p</i> = 0.035; OR = 9.5, <i>p</i> = 0.003) organ quality were independent predictors of EAD. Our data do not support the notion that aprotinin prevents nor attenuates PRS, EAD or mortality.Anna B. RoehlAnne AndertKarsten JungeUlf P. NeumannMarc HeinFelix KorkMDPI AGarticleaprotininliver transplantationhumanextended donor criteriaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5232, p 5232 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aprotinin liver transplantation human extended donor criteria Medicine R
spellingShingle	aprotinin liver transplantation human extended donor criteria Medicine R Anna B. Roehl Anne Andert Karsten Junge Ulf P. Neumann Marc Hein Felix Kork Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis
description	The number of patients awaiting liver transplantation still widely exceeds the number of donated organs available. Patients receiving extended criteria donor (ECD) organs are especially prone to an aggravated ischemia reperfusion syndrome during liver transplantation leading to massive hemodynamic stress and possible impairment in organ function. Previous studies have demonstrated aprotinin to ameliorate reperfusion injury and early graft survival. In this single center retrospective analysis of 84 propensity score matched patients out of 274 liver transplantation patients between 2010 and 2014 (OLT), we describe the association of aprotinin with postreperfusion syndrome (PRS), early allograft dysfunction (EAD: INR 1,6, AST/ALT > 2000 within 7–10 days) and recipient survival. The incidence of PRS (52.4% vs. 47.6%) and 30-day mortality did not differ (4.8 vs. 0%; <i>p</i> = 0.152) but patients treated with aprotinin suffered more often from EAD (64.3% vs. 40.5%, <i>p</i> = 0.029) compared to controls. Acceptable or poor (OR = 3.3, <i>p</i> = 0.035; OR = 9.5, <i>p</i> = 0.003) organ quality were independent predictors of EAD. Our data do not support the notion that aprotinin prevents nor attenuates PRS, EAD or mortality.
format	article
author	Anna B. Roehl Anne Andert Karsten Junge Ulf P. Neumann Marc Hein Felix Kork
author_facet	Anna B. Roehl Anne Andert Karsten Junge Ulf P. Neumann Marc Hein Felix Kork
author_sort	Anna B. Roehl
title	Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis
title_short	Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis
title_full	Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis
title_fullStr	Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis
title_full_unstemmed	Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis
title_sort	effect of aprotinin on liver injury after transplantation of extended criteria donor grafts in humans: a retrospective propensity score matched cohort analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fbc14532e65341cf9220138f86f6227b
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Effect of Aprotinin on Liver Injury after Transplantation of Extended Criteria Donor Grafts in Humans: A Retrospective Propensity Score Matched Cohort Analysis

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