Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions

Traction force microscopy is an effective method for measuring cellular forces but it is limited by planar geometry. Here the authors develop a facile method to produce deformable hydrogel particles and a reference-free computational method to resolve surface traction forces from particle shape defo...

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Auteurs principaux:	Daan Vorselen, Yifan Wang, Miguel M. de Jesus, Pavak K. Shah, Matthew J. Footer, Morgan Huse, Wei Cai, Julie A. Theriot
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/fbc3f6afb17f46f49e6de46d02f86e78
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spelling	oai:doaj.org-article:fbc3f6afb17f46f49e6de46d02f86e782021-12-02T15:33:52ZMicroparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions10.1038/s41467-019-13804-z2041-1723https://doaj.org/article/fbc3f6afb17f46f49e6de46d02f86e782020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13804-zhttps://doaj.org/toc/2041-1723Traction force microscopy is an effective method for measuring cellular forces but it is limited by planar geometry. Here the authors develop a facile method to produce deformable hydrogel particles and a reference-free computational method to resolve surface traction forces from particle shape deformation.Daan VorselenYifan WangMiguel M. de JesusPavak K. ShahMatthew J. FooterMorgan HuseWei CaiJulie A. TheriotNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daan Vorselen Yifan Wang Miguel M. de Jesus Pavak K. Shah Matthew J. Footer Morgan Huse Wei Cai Julie A. Theriot Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
description	Traction force microscopy is an effective method for measuring cellular forces but it is limited by planar geometry. Here the authors develop a facile method to produce deformable hydrogel particles and a reference-free computational method to resolve surface traction forces from particle shape deformation.
format	article
author	Daan Vorselen Yifan Wang Miguel M. de Jesus Pavak K. Shah Matthew J. Footer Morgan Huse Wei Cai Julie A. Theriot
author_facet	Daan Vorselen Yifan Wang Miguel M. de Jesus Pavak K. Shah Matthew J. Footer Morgan Huse Wei Cai Julie A. Theriot
author_sort	Daan Vorselen
title	Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
title_short	Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
title_full	Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
title_fullStr	Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
title_full_unstemmed	Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
title_sort	microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fbc3f6afb17f46f49e6de46d02f86e78
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_version_	1718387001179242496

Microparticle traction force microscopy reveals subcellular force exertion patterns in immune cell–target interactions

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