Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.

Antimicrobial peptides have attracted much interest as a novel class of antibiotics against a variety of microbes including antibiotics resistant strains. In this study, a new cationic antimicrobial peptide Hp1404 was identified from the scorpion Heterometrus petersii, which is an amphipathic α-heli...

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Autores principales:	Zhongjie Li, Xiaobo Xu, Lanxia Meng, Qian Zhang, Luyang Cao, Wenxin Li, Yingliang Wu, Zhijian Cao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbc4cf6e402e428dac2f54de5f300e8b
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spelling	oai:doaj.org-article:fbc4cf6e402e428dac2f54de5f300e8b2021-11-18T08:19:26ZHp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.1932-620310.1371/journal.pone.0097539https://doaj.org/article/fbc4cf6e402e428dac2f54de5f300e8b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24826994/?tool=EBIhttps://doaj.org/toc/1932-6203Antimicrobial peptides have attracted much interest as a novel class of antibiotics against a variety of microbes including antibiotics resistant strains. In this study, a new cationic antimicrobial peptide Hp1404 was identified from the scorpion Heterometrus petersii, which is an amphipathic α-helical peptide and has a specific inhibitory activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. Hp1404 can penetrate the membrane of S. aureus at low concentration, and disrupts the cellular membrane directly at super high concentration. S. aureus does not develop drug resistance after multiple treatments with Hp1404 at sub MIC concentration, which is possibly associated with the antibacterial mechanism of the peptide. In addition, Hp1404 has low toxicity to both mammalian cells (HC₅₀ = 226.6 µg/mL and CC₅₀ > 100 µg/mL) and balb-c mice (Non-toxicity at 80 mg/Kg by intraperitoneal injection and LD₅₀ = 89.8 mg/Kg by intravenous injection). Interestingly, Hp1404 can improve the survival rate of the MRSA infected balb-c mice in the peritonitis model. Taken together, Hp1404 may have potential applications as an antibacterial agent.Zhongjie LiXiaobo XuLanxia MengQian ZhangLuyang CaoWenxin LiYingliang WuZhijian CaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97539 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhongjie Li Xiaobo Xu Lanxia Meng Qian Zhang Luyang Cao Wenxin Li Yingliang Wu Zhijian Cao Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.
description	Antimicrobial peptides have attracted much interest as a novel class of antibiotics against a variety of microbes including antibiotics resistant strains. In this study, a new cationic antimicrobial peptide Hp1404 was identified from the scorpion Heterometrus petersii, which is an amphipathic α-helical peptide and has a specific inhibitory activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus. Hp1404 can penetrate the membrane of S. aureus at low concentration, and disrupts the cellular membrane directly at super high concentration. S. aureus does not develop drug resistance after multiple treatments with Hp1404 at sub MIC concentration, which is possibly associated with the antibacterial mechanism of the peptide. In addition, Hp1404 has low toxicity to both mammalian cells (HC₅₀ = 226.6 µg/mL and CC₅₀ > 100 µg/mL) and balb-c mice (Non-toxicity at 80 mg/Kg by intraperitoneal injection and LD₅₀ = 89.8 mg/Kg by intravenous injection). Interestingly, Hp1404 can improve the survival rate of the MRSA infected balb-c mice in the peritonitis model. Taken together, Hp1404 may have potential applications as an antibacterial agent.
format	article
author	Zhongjie Li Xiaobo Xu Lanxia Meng Qian Zhang Luyang Cao Wenxin Li Yingliang Wu Zhijian Cao
author_facet	Zhongjie Li Xiaobo Xu Lanxia Meng Qian Zhang Luyang Cao Wenxin Li Yingliang Wu Zhijian Cao
author_sort	Zhongjie Li
title	Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.
title_short	Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.
title_full	Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.
title_fullStr	Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.
title_full_unstemmed	Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.
title_sort	hp1404, a new antimicrobial peptide from the scorpion heterometrus petersii.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fbc4cf6e402e428dac2f54de5f300e8b
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Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii.

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