New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study.
<h4>Aims</h4>To examine the long-term risk of hyperthyroidism in patients admitted to hospital with new-onset AF. Hyperthyroidism is a well-known risk factor for atrial fibrillation (AF), but it is unknown whether new-onset AF predicts later-occurring hyperthyroidism.<h4>Methods an...
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2013
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oai:doaj.org-article:fbc592ed03a54e2e9acb304fc519a8792021-11-18T07:55:21ZNew-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study.1932-620310.1371/journal.pone.0057893https://doaj.org/article/fbc592ed03a54e2e9acb304fc519a8792013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23469097/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>To examine the long-term risk of hyperthyroidism in patients admitted to hospital with new-onset AF. Hyperthyroidism is a well-known risk factor for atrial fibrillation (AF), but it is unknown whether new-onset AF predicts later-occurring hyperthyroidism.<h4>Methods and results</h4>All patients admitted with new-onset AF in Denmark from 1997-2009, and their present and subsequent use of anti-thyroid medication was identified by individual-level linkage of nationwide registries. Patients with previous thyroid diagnosis or thyroid medication use were excluded. Development of hyperthyroidism was assessed as initiation of methimazole or propylthiouracil up to a 13-year period. Risk of hyperthyroidism was analysed by Poisson regression models adjusted for important confounders such as amiodarone treatment. Non-AF individuals from the general population served as reference. A total of 145,623 patients with new-onset AF were included (mean age 66.4 years [SD ±13.2] and 55.3% males) of whom 3% (4,620 events; 62.2% women) developed hyperthyroidism in the post-hospitalization period compared to 1% (48,609 events; 82% women) in the general population (n = 3,866,889). In both women and men we found a significantly increased risk of hyperthyroidism associated with new-onset AF compared to individuals in the general population. The highest risk was found in middle-aged men and was consistently increased throughout the 13-year period of observation. The results were confirmed in a substudy analysis of 527,352 patients who had thyroid screening done.<h4>Conclusion</h4>New-onset AF seems to be a predictor of hyperthyroidism. Increased focus on subsequent risk of hyperthyroidism in patients with new-onset AF is warranted.Christian SelmerMorten Lock HansenJonas Bjerring OlesenCharlotte MérieJesper LindhardsenAnne-Marie Schjerning OlsenJesper Clausager MadsenUlla SchmidtJens FaberPeter Riis HansenOle Dyg PedersenChristian Torp-PedersenGunnar Hilmar GislasonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57893 (2013) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Christian Selmer Morten Lock Hansen Jonas Bjerring Olesen Charlotte Mérie Jesper Lindhardsen Anne-Marie Schjerning Olsen Jesper Clausager Madsen Ulla Schmidt Jens Faber Peter Riis Hansen Ole Dyg Pedersen Christian Torp-Pedersen Gunnar Hilmar Gislason New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study. |
| description |
<h4>Aims</h4>To examine the long-term risk of hyperthyroidism in patients admitted to hospital with new-onset AF. Hyperthyroidism is a well-known risk factor for atrial fibrillation (AF), but it is unknown whether new-onset AF predicts later-occurring hyperthyroidism.<h4>Methods and results</h4>All patients admitted with new-onset AF in Denmark from 1997-2009, and their present and subsequent use of anti-thyroid medication was identified by individual-level linkage of nationwide registries. Patients with previous thyroid diagnosis or thyroid medication use were excluded. Development of hyperthyroidism was assessed as initiation of methimazole or propylthiouracil up to a 13-year period. Risk of hyperthyroidism was analysed by Poisson regression models adjusted for important confounders such as amiodarone treatment. Non-AF individuals from the general population served as reference. A total of 145,623 patients with new-onset AF were included (mean age 66.4 years [SD ±13.2] and 55.3% males) of whom 3% (4,620 events; 62.2% women) developed hyperthyroidism in the post-hospitalization period compared to 1% (48,609 events; 82% women) in the general population (n = 3,866,889). In both women and men we found a significantly increased risk of hyperthyroidism associated with new-onset AF compared to individuals in the general population. The highest risk was found in middle-aged men and was consistently increased throughout the 13-year period of observation. The results were confirmed in a substudy analysis of 527,352 patients who had thyroid screening done.<h4>Conclusion</h4>New-onset AF seems to be a predictor of hyperthyroidism. Increased focus on subsequent risk of hyperthyroidism in patients with new-onset AF is warranted. |
| format |
article |
| author |
Christian Selmer Morten Lock Hansen Jonas Bjerring Olesen Charlotte Mérie Jesper Lindhardsen Anne-Marie Schjerning Olsen Jesper Clausager Madsen Ulla Schmidt Jens Faber Peter Riis Hansen Ole Dyg Pedersen Christian Torp-Pedersen Gunnar Hilmar Gislason |
| author_facet |
Christian Selmer Morten Lock Hansen Jonas Bjerring Olesen Charlotte Mérie Jesper Lindhardsen Anne-Marie Schjerning Olsen Jesper Clausager Madsen Ulla Schmidt Jens Faber Peter Riis Hansen Ole Dyg Pedersen Christian Torp-Pedersen Gunnar Hilmar Gislason |
| author_sort |
Christian Selmer |
| title |
New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study. |
| title_short |
New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study. |
| title_full |
New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study. |
| title_fullStr |
New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study. |
| title_full_unstemmed |
New-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study. |
| title_sort |
new-onset atrial fibrillation is a predictor of subsequent hyperthyroidism: a nationwide cohort study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/fbc592ed03a54e2e9acb304fc519a879 |
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