NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

Nlrp3 inflammasome activation requires Nek7 recruitment to drive ASC speck formation. Here the authors show how Nlrp3 phosphorylation events control this Nek7 recruitment.

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Autores principales:	Tingting Niu, Charlotte De Rosny, Séverine Chautard, Amaury Rey, Danish Patoli, Marine Groslambert, Camille Cosson, Brice Lagrange, Zhirong Zhang, Orane Visvikis, Sabine Hacot, Maggy Hologne, Olivier Walker, Jeimin Wong, Ping Wang, Roméo Ricci, Thomas Henry, Laurent Boyer, Virginie Petrilli, Bénédicte F. Py
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbcf468393234f91b37ce912376f58ab
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spelling	oai:doaj.org-article:fbcf468393234f91b37ce912376f58ab2021-12-02T17:13:18ZNLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly10.1038/s41467-021-26142-w2041-1723https://doaj.org/article/fbcf468393234f91b37ce912376f58ab2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26142-whttps://doaj.org/toc/2041-1723Nlrp3 inflammasome activation requires Nek7 recruitment to drive ASC speck formation. Here the authors show how Nlrp3 phosphorylation events control this Nek7 recruitment.Tingting NiuCharlotte De RosnySéverine ChautardAmaury ReyDanish PatoliMarine GroslambertCamille CossonBrice LagrangeZhirong ZhangOrane VisvikisSabine HacotMaggy HologneOlivier WalkerJeimin WongPing WangRoméo RicciThomas HenryLaurent BoyerVirginie PetrilliBénédicte F. PyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tingting Niu Charlotte De Rosny Séverine Chautard Amaury Rey Danish Patoli Marine Groslambert Camille Cosson Brice Lagrange Zhirong Zhang Orane Visvikis Sabine Hacot Maggy Hologne Olivier Walker Jeimin Wong Ping Wang Roméo Ricci Thomas Henry Laurent Boyer Virginie Petrilli Bénédicte F. Py NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
description	Nlrp3 inflammasome activation requires Nek7 recruitment to drive ASC speck formation. Here the authors show how Nlrp3 phosphorylation events control this Nek7 recruitment.
format	article
author	Tingting Niu Charlotte De Rosny Séverine Chautard Amaury Rey Danish Patoli Marine Groslambert Camille Cosson Brice Lagrange Zhirong Zhang Orane Visvikis Sabine Hacot Maggy Hologne Olivier Walker Jeimin Wong Ping Wang Roméo Ricci Thomas Henry Laurent Boyer Virginie Petrilli Bénédicte F. Py
author_facet	Tingting Niu Charlotte De Rosny Séverine Chautard Amaury Rey Danish Patoli Marine Groslambert Camille Cosson Brice Lagrange Zhirong Zhang Orane Visvikis Sabine Hacot Maggy Hologne Olivier Walker Jeimin Wong Ping Wang Roméo Ricci Thomas Henry Laurent Boyer Virginie Petrilli Bénédicte F. Py
author_sort	Tingting Niu
title	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_short	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_full	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_fullStr	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_full_unstemmed	NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly
title_sort	nlrp3 phosphorylation in its lrr domain critically regulates inflammasome assembly
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbcf468393234f91b37ce912376f58ab
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NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

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