A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6

Abstract Retinoids are a group of vitamin A-related chemicals that are essential to chordate mammals. They regulate a number of basic processes, including embryogenesis and vision. From ingestion to metabolism and the subsequent cellular effects, retinoid levels are tightly regulated in the organism...

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Autores principales:	Vinesh Dhokia, Salvador Macip
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/fbd0826fab0c4e14846d06a65b526d2d
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spelling	oai:doaj.org-article:fbd0826fab0c4e14846d06a65b526d2d2021-11-21T12:08:51ZA master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA610.1038/s41420-021-00754-z2058-7716https://doaj.org/article/fbd0826fab0c4e14846d06a65b526d2d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41420-021-00754-zhttps://doaj.org/toc/2058-7716Abstract Retinoids are a group of vitamin A-related chemicals that are essential to chordate mammals. They regulate a number of basic processes, including embryogenesis and vision. From ingestion to metabolism and the subsequent cellular effects, retinoid levels are tightly regulated in the organism to prevent toxicity. One component of this network, the membrane receptor STRA6, has been shown to be essential in facilitating the cellular entry and exit of retinol. However, recent data suggests that STRA6 may not function merely as a retinoid transporter but also act as a complex signalling hub in its own right, being able to affect cell fate through the integration of retinoid signalling with other key pathways, such as those involving p53, JAK/STAT, Wnt/β catenin and calcium. This may open new therapeutic strategies in diseases like cancer, where these pathways are often compromised. Here, we look at the growing evidence regarding the novel roles of STRA6 beyond its well characterized classic functions.Vinesh DhokiaSalvador MacipNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Vinesh Dhokia Salvador Macip A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
description	Abstract Retinoids are a group of vitamin A-related chemicals that are essential to chordate mammals. They regulate a number of basic processes, including embryogenesis and vision. From ingestion to metabolism and the subsequent cellular effects, retinoid levels are tightly regulated in the organism to prevent toxicity. One component of this network, the membrane receptor STRA6, has been shown to be essential in facilitating the cellular entry and exit of retinol. However, recent data suggests that STRA6 may not function merely as a retinoid transporter but also act as a complex signalling hub in its own right, being able to affect cell fate through the integration of retinoid signalling with other key pathways, such as those involving p53, JAK/STAT, Wnt/β catenin and calcium. This may open new therapeutic strategies in diseases like cancer, where these pathways are often compromised. Here, we look at the growing evidence regarding the novel roles of STRA6 beyond its well characterized classic functions.
format	article
author	Vinesh Dhokia Salvador Macip
author_facet	Vinesh Dhokia Salvador Macip
author_sort	Vinesh Dhokia
title	A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
title_short	A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
title_full	A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
title_fullStr	A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
title_full_unstemmed	A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
title_sort	master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor stra6
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/fbd0826fab0c4e14846d06a65b526d2d
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A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6

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