Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

The Spike protein of SARS-CoV-2 has a C-terminal cytoplasmic tail. Here the authors show that this tail binds trafficking machinery via sequences that appear optimised to ensure that Spike accumulates at the site of viral budding in the Golgi but that some can also traffic to the cell surface to ind...

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Autores principales:	Jérôme Cattin-Ortolá, Lawrence G. Welch, Sarah L. Maslen, Guido Papa, Leo C. James, Sean Munro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbd2667f0c0d43b0837fb514639c3ee9
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spelling	oai:doaj.org-article:fbd2667f0c0d43b0837fb514639c3ee92021-12-02T17:19:40ZSequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation10.1038/s41467-021-25589-12041-1723https://doaj.org/article/fbd2667f0c0d43b0837fb514639c3ee92021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25589-1https://doaj.org/toc/2041-1723The Spike protein of SARS-CoV-2 has a C-terminal cytoplasmic tail. Here the authors show that this tail binds trafficking machinery via sequences that appear optimised to ensure that Spike accumulates at the site of viral budding in the Golgi but that some can also traffic to the cell surface to induce syncytia formation.Jérôme Cattin-OrtoláLawrence G. WelchSarah L. MaslenGuido PapaLeo C. JamesSean MunroNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jérôme Cattin-Ortolá Lawrence G. Welch Sarah L. Maslen Guido Papa Leo C. James Sean Munro Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
description	The Spike protein of SARS-CoV-2 has a C-terminal cytoplasmic tail. Here the authors show that this tail binds trafficking machinery via sequences that appear optimised to ensure that Spike accumulates at the site of viral budding in the Golgi but that some can also traffic to the cell surface to induce syncytia formation.
format	article
author	Jérôme Cattin-Ortolá Lawrence G. Welch Sarah L. Maslen Guido Papa Leo C. James Sean Munro
author_facet	Jérôme Cattin-Ortolá Lawrence G. Welch Sarah L. Maslen Guido Papa Leo C. James Sean Munro
author_sort	Jérôme Cattin-Ortolá
title	Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
title_short	Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
title_full	Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
title_fullStr	Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
title_full_unstemmed	Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
title_sort	sequences in the cytoplasmic tail of sars-cov-2 spike facilitate expression at the cell surface and syncytia formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbd2667f0c0d43b0837fb514639c3ee9
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Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

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