Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years

<h4>Background</h4> Atrial fibrillation (AF) has a heterogeneous pathophysiology according to individual patient characteristics. This study aimed to identify the effects of widely known risk factors on AF incidence according to age and to elucidate the clinical implications of these eff...

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Autores principales:	In-Soo Kim, Yeon-Jik Choi, Eui-Young Choi, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Jong-Youn Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbd42e7a35bc48feb0863f6d65c02ab7
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spelling	oai:doaj.org-article:fbd42e7a35bc48feb0863f6d65c02ab72021-11-25T06:19:33ZComparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years1932-6203https://doaj.org/article/fbd42e7a35bc48feb0863f6d65c02ab72021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601466/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Atrial fibrillation (AF) has a heterogeneous pathophysiology according to individual patient characteristics. This study aimed to identify the effects of widely known risk factors on AF incidence according to age and to elucidate the clinical implications of these effects. <h4>Methods and results</h4> We analyzed data from 501,668 subjects (≥18years old) without AF and valvular heart disease from the Korean National Health Insurance Service-National Sample Cohort. The total population was divided into two groups according to age, <60years and ≥60years. AF occurred in 0.7% of the overall population (3,416 of 501,668) during the follow-up period (mean 47.6 months). In Cox regression analysis, age, male sex, previous ischemic stroke, heart failure, and hypertension were related to increased risk of new-onset AF in both age groups. Especially in the <60years age group, risk of new-onset AF was increased by relatively modifiable risk factors: obesity (body mass index ≥25kg/m2; hazard ratio[HR] 1.37 [1.22–1.55], p<0.001, interaction p<0.001), and hypertension (HR 1.93[1.69–2.22], p<0.001, interaction p<0.001). Although interactions were not significant, chronic obstructive pulmonary disease (HR 1.41[1.24–1.60], p<0.001) and chronic kidney disease (HR 1.28[1.15–1.41], p<0.001) showed increased trends of the risk of new-onset AF in the ≥60years age group. <h4>Conclusion</h4> The risk profile for new-onset AF was somewhat different between the <60years and the ≥60years age groups. Compared to the ≥60years group, relatively modifiable risk factors (such as obesity and hypertension) had a greater impact on AF incidence in the <60years age group. Different management strategies to prevent AF development according to age may be needed.In-Soo KimYeon-Jik ChoiEui-Young ChoiPil-Ki MinYoung Won YoonByoung Kwon LeeBum-Kee HongSe-Joong RimHyuck Moon KwonJong-Youn KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q In-Soo Kim Yeon-Jik Choi Eui-Young Choi Pil-Ki Min Young Won Yoon Byoung Kwon Lee Bum-Kee Hong Se-Joong Rim Hyuck Moon Kwon Jong-Youn Kim Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
description	<h4>Background</h4> Atrial fibrillation (AF) has a heterogeneous pathophysiology according to individual patient characteristics. This study aimed to identify the effects of widely known risk factors on AF incidence according to age and to elucidate the clinical implications of these effects. <h4>Methods and results</h4> We analyzed data from 501,668 subjects (≥18years old) without AF and valvular heart disease from the Korean National Health Insurance Service-National Sample Cohort. The total population was divided into two groups according to age, <60years and ≥60years. AF occurred in 0.7% of the overall population (3,416 of 501,668) during the follow-up period (mean 47.6 months). In Cox regression analysis, age, male sex, previous ischemic stroke, heart failure, and hypertension were related to increased risk of new-onset AF in both age groups. Especially in the <60years age group, risk of new-onset AF was increased by relatively modifiable risk factors: obesity (body mass index ≥25kg/m2; hazard ratio[HR] 1.37 [1.22–1.55], p<0.001, interaction p<0.001), and hypertension (HR 1.93[1.69–2.22], p<0.001, interaction p<0.001). Although interactions were not significant, chronic obstructive pulmonary disease (HR 1.41[1.24–1.60], p<0.001) and chronic kidney disease (HR 1.28[1.15–1.41], p<0.001) showed increased trends of the risk of new-onset AF in the ≥60years age group. <h4>Conclusion</h4> The risk profile for new-onset AF was somewhat different between the <60years and the ≥60years age groups. Compared to the ≥60years group, relatively modifiable risk factors (such as obesity and hypertension) had a greater impact on AF incidence in the <60years age group. Different management strategies to prevent AF development according to age may be needed.
format	article
author	In-Soo Kim Yeon-Jik Choi Eui-Young Choi Pil-Ki Min Young Won Yoon Byoung Kwon Lee Bum-Kee Hong Se-Joong Rim Hyuck Moon Kwon Jong-Youn Kim
author_facet	In-Soo Kim Yeon-Jik Choi Eui-Young Choi Pil-Ki Min Young Won Yoon Byoung Kwon Lee Bum-Kee Hong Se-Joong Rim Hyuck Moon Kwon Jong-Youn Kim
author_sort	In-Soo Kim
title	Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
title_short	Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
title_full	Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
title_fullStr	Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
title_full_unstemmed	Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
title_sort	comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fbd42e7a35bc48feb0863f6d65c02ab7
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Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years

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