Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 su...

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Autores principales:	Mahboobeh-Sadat Hosseini, Fereshteh Salarvand, Amir Houshang Ehsani, Pedram Noormohammadpour, Shadi Azizzadeh, Mohaddese Mousavi, Mona Morsali
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2019
Materias:	skin cancer squamous cell carcinoma vitamin D cancer epidemiology supplements Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/fbd68cd94d954b84b4f4e7906bb65fef
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spelling	oai:doaj.org-article:fbd68cd94d954b84b4f4e7906bb65fef2021-11-17T08:29:14ZRelationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population10.5826/dpc.0904a062160-9381https://doaj.org/article/fbd68cd94d954b84b4f4e7906bb65fef2019-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/687https://doaj.org/toc/2160-9381 Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population. Mahboobeh-Sadat HosseiniFereshteh SalarvandAmir Houshang EhsaniPedram NoormohammadpourShadi AzizzadehMohaddese MousaviMona MorsaliMattioli1885articleskin cancersquamous cell carcinomavitamin Dcancer epidemiologysupplementsDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 9, Iss 4 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin cancer squamous cell carcinoma vitamin D cancer epidemiology supplements Dermatology RL1-803
spellingShingle	skin cancer squamous cell carcinoma vitamin D cancer epidemiology supplements Dermatology RL1-803 Mahboobeh-Sadat Hosseini Fereshteh Salarvand Amir Houshang Ehsani Pedram Noormohammadpour Shadi Azizzadeh Mohaddese Mousavi Mona Morsali Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population
description	Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.
format	article
author	Mahboobeh-Sadat Hosseini Fereshteh Salarvand Amir Houshang Ehsani Pedram Noormohammadpour Shadi Azizzadeh Mohaddese Mousavi Mona Morsali
author_facet	Mahboobeh-Sadat Hosseini Fereshteh Salarvand Amir Houshang Ehsani Pedram Noormohammadpour Shadi Azizzadeh Mohaddese Mousavi Mona Morsali
author_sort	Mahboobeh-Sadat Hosseini
title	Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population
title_short	Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population
title_full	Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population
title_fullStr	Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population
title_full_unstemmed	Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population
title_sort	relationship between level of serum 25-hydroxyvitamin d and risk of squamous cell carcinoma in an iranian population
publisher	Mattioli1885
publishDate	2019
url	https://doaj.org/article/fbd68cd94d954b84b4f4e7906bb65fef
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Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

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