Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplas...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Iwei Yeh, Ursula E. Lang, Emeline Durieux, Meng Kian Tee, Aparna Jorapur, A. Hunter Shain, Veronique Haddad, Daniel Pissaloux, Xu Chen, Lorenzo Cerroni, Robert L. Judson, Philip E. LeBoit, Timothy H. McCalmont, Boris C. Bastian, Arnaud de la Fouchardière
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/fbd6a7307720476793d06dd7588353f5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplasms.

Ejemplares similares