Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplas...

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Autores principales:	Iwei Yeh, Ursula E. Lang, Emeline Durieux, Meng Kian Tee, Aparna Jorapur, A. Hunter Shain, Veronique Haddad, Daniel Pissaloux, Xu Chen, Lorenzo Cerroni, Robert L. Judson, Philip E. LeBoit, Timothy H. McCalmont, Boris C. Bastian, Arnaud de la Fouchardière
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbd6a7307720476793d06dd7588353f5
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spelling	oai:doaj.org-article:fbd6a7307720476793d06dd7588353f52021-12-02T14:40:34ZCombined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi10.1038/s41467-017-00758-32041-1723https://doaj.org/article/fbd6a7307720476793d06dd7588353f52017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00758-3https://doaj.org/toc/2041-1723Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplasms.Iwei YehUrsula E. LangEmeline DurieuxMeng Kian TeeAparna JorapurA. Hunter ShainVeronique HaddadDaniel PissalouxXu ChenLorenzo CerroniRobert L. JudsonPhilip E. LeBoitTimothy H. McCalmontBoris C. BastianArnaud de la FouchardièreNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iwei Yeh Ursula E. Lang Emeline Durieux Meng Kian Tee Aparna Jorapur A. Hunter Shain Veronique Haddad Daniel Pissaloux Xu Chen Lorenzo Cerroni Robert L. Judson Philip E. LeBoit Timothy H. McCalmont Boris C. Bastian Arnaud de la Fouchardière Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
description	Deep penetrating nevi (DPN) are unusual melanocytic neoplasms with unknown genetic drivers. Here the authors show that majority of DPN harbor activating mutations in the β-catenin and the MAP-kinase pathways; this characteristic can help in the classification and grading of these distinctive neoplasms.
format	article
author	Iwei Yeh Ursula E. Lang Emeline Durieux Meng Kian Tee Aparna Jorapur A. Hunter Shain Veronique Haddad Daniel Pissaloux Xu Chen Lorenzo Cerroni Robert L. Judson Philip E. LeBoit Timothy H. McCalmont Boris C. Bastian Arnaud de la Fouchardière
author_facet	Iwei Yeh Ursula E. Lang Emeline Durieux Meng Kian Tee Aparna Jorapur A. Hunter Shain Veronique Haddad Daniel Pissaloux Xu Chen Lorenzo Cerroni Robert L. Judson Philip E. LeBoit Timothy H. McCalmont Boris C. Bastian Arnaud de la Fouchardière
author_sort	Iwei Yeh
title	Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
title_short	Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
title_full	Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
title_fullStr	Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
title_full_unstemmed	Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
title_sort	combined activation of map kinase pathway and β-catenin signaling cause deep penetrating nevi
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fbd6a7307720476793d06dd7588353f5
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Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi

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