Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer

Activation of an immune response is critical for the efficacy of cancer therapies. Here, the authors show that combination of ROCK inhibitor with chemotherapeutics that induce immunogenic cell death of cancer cells leads to increased dendritic cells’ maturation and synergistic CD8+ cytotoxic T cell...

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Autores principales:	Gi-Hoon Nam, Eun Jung Lee, Yoon Kyoung Kim, Yeonsun Hong, Yoonjeong Choi, Myung-Jeom Ryu, Jiwan Woo, Yakdol Cho, Dong June Ahn, Yoosoo Yang, Ick-Chan Kwon, Seung-Yoon Park, In-San Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbd7c145700540adbfdef82b4d5c68e6
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spelling	oai:doaj.org-article:fbd7c145700540adbfdef82b4d5c68e62021-12-02T14:39:47ZCombined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer10.1038/s41467-018-04607-92041-1723https://doaj.org/article/fbd7c145700540adbfdef82b4d5c68e62018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04607-9https://doaj.org/toc/2041-1723Activation of an immune response is critical for the efficacy of cancer therapies. Here, the authors show that combination of ROCK inhibitor with chemotherapeutics that induce immunogenic cell death of cancer cells leads to increased dendritic cells’ maturation and synergistic CD8+ cytotoxic T cell priming and infiltration into the tumours, leading to suppressed tumour growth and improved overall survival in syngeneic and genetically engineered tumour models.Gi-Hoon NamEun Jung LeeYoon Kyoung KimYeonsun HongYoonjeong ChoiMyung-Jeom RyuJiwan WooYakdol ChoDong June AhnYoosoo YangIck-Chan KwonSeung-Yoon ParkIn-San KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gi-Hoon Nam Eun Jung Lee Yoon Kyoung Kim Yeonsun Hong Yoonjeong Choi Myung-Jeom Ryu Jiwan Woo Yakdol Cho Dong June Ahn Yoosoo Yang Ick-Chan Kwon Seung-Yoon Park In-San Kim Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
description	Activation of an immune response is critical for the efficacy of cancer therapies. Here, the authors show that combination of ROCK inhibitor with chemotherapeutics that induce immunogenic cell death of cancer cells leads to increased dendritic cells’ maturation and synergistic CD8+ cytotoxic T cell priming and infiltration into the tumours, leading to suppressed tumour growth and improved overall survival in syngeneic and genetically engineered tumour models.
format	article
author	Gi-Hoon Nam Eun Jung Lee Yoon Kyoung Kim Yeonsun Hong Yoonjeong Choi Myung-Jeom Ryu Jiwan Woo Yakdol Cho Dong June Ahn Yoosoo Yang Ick-Chan Kwon Seung-Yoon Park In-San Kim
author_facet	Gi-Hoon Nam Eun Jung Lee Yoon Kyoung Kim Yeonsun Hong Yoonjeong Choi Myung-Jeom Ryu Jiwan Woo Yakdol Cho Dong June Ahn Yoosoo Yang Ick-Chan Kwon Seung-Yoon Park In-San Kim
author_sort	Gi-Hoon Nam
title	Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
title_short	Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
title_full	Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
title_fullStr	Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
title_full_unstemmed	Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
title_sort	combined rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fbd7c145700540adbfdef82b4d5c68e6
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Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer

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