Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway

Cross-presentation, or the presentation of exogenous antigens on MHC-I, is thought to be restricted to dendritic cells (DCs). Here the authors show that human DCs and macrophages developed in vivo from monocytes can both perform cross-presentation using a non-conventional pathway, but only DCs are c...

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Autores principales:	Tsing-Lee Tang-Huau, Paul Gueguen, Christel Goudot, Mélanie Durand, Mylène Bohec, Sylvain Baulande, Benoit Pasquier, Sebastian Amigorena, Elodie Segura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbdccbe896344f34ab585eae4a11785d
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spelling	oai:doaj.org-article:fbdccbe896344f34ab585eae4a11785d2021-12-02T16:56:43ZHuman in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway10.1038/s41467-018-04985-02041-1723https://doaj.org/article/fbdccbe896344f34ab585eae4a11785d2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04985-0https://doaj.org/toc/2041-1723Cross-presentation, or the presentation of exogenous antigens on MHC-I, is thought to be restricted to dendritic cells (DCs). Here the authors show that human DCs and macrophages developed in vivo from monocytes can both perform cross-presentation using a non-conventional pathway, but only DCs are capable of inducing cytotoxic CD8+ T cells.Tsing-Lee Tang-HuauPaul GueguenChristel GoudotMélanie DurandMylène BohecSylvain BaulandeBenoit PasquierSebastian AmigorenaElodie SeguraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tsing-Lee Tang-Huau Paul Gueguen Christel Goudot Mélanie Durand Mylène Bohec Sylvain Baulande Benoit Pasquier Sebastian Amigorena Elodie Segura Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
description	Cross-presentation, or the presentation of exogenous antigens on MHC-I, is thought to be restricted to dendritic cells (DCs). Here the authors show that human DCs and macrophages developed in vivo from monocytes can both perform cross-presentation using a non-conventional pathway, but only DCs are capable of inducing cytotoxic CD8+ T cells.
format	article
author	Tsing-Lee Tang-Huau Paul Gueguen Christel Goudot Mélanie Durand Mylène Bohec Sylvain Baulande Benoit Pasquier Sebastian Amigorena Elodie Segura
author_facet	Tsing-Lee Tang-Huau Paul Gueguen Christel Goudot Mélanie Durand Mylène Bohec Sylvain Baulande Benoit Pasquier Sebastian Amigorena Elodie Segura
author_sort	Tsing-Lee Tang-Huau
title	Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
title_short	Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
title_full	Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
title_fullStr	Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
title_full_unstemmed	Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
title_sort	human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fbdccbe896344f34ab585eae4a11785d
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Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway

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