The effect of anxiety and depression on progression of glaucoma

Abstract Glaucoma is considered a chronic disease that requires lifelong management. Chronic diseases are known to be highly associated with psychological disturbances such as depression and anxiety. There have also been many studies on association between anxiety or depression and glaucoma. The maj...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Da Young Shin, Kyoung In Jung, Hae Young Lopilly Park, Chan Kee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbddf2dc8e4f4fc28ba9822d023b0081
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fbddf2dc8e4f4fc28ba9822d023b0081
record_format	dspace
spelling	oai:doaj.org-article:fbddf2dc8e4f4fc28ba9822d023b00812021-12-02T10:49:34ZThe effect of anxiety and depression on progression of glaucoma10.1038/s41598-021-81512-02045-2322https://doaj.org/article/fbddf2dc8e4f4fc28ba9822d023b00812021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81512-0https://doaj.org/toc/2045-2322Abstract Glaucoma is considered a chronic disease that requires lifelong management. Chronic diseases are known to be highly associated with psychological disturbances such as depression and anxiety. There have also been many studies on association between anxiety or depression and glaucoma. The majority of these studies explained that the glaucoma diagnosis causes anxiety or depression. However, It is also necessary to evaluate whether the psychological disturbance itself affect glaucoma. Therefore, we investigated the association of anxiety and depression with glaucoma progression, and elucidate mechanisms underlying that. We included 251 eyes with open angle glaucoma who were followed up for at least 2 years in this retrospective case–control study. The Beck Anxiety Inventory (BAI) and Beck Depressive Inventory-II (BDI-II) were used to assess anxiety and depression in glaucoma patients. Patients were classified into groups (high-anxiety group; HA-G, low-anxiety group; LA-G, high-depression group; HD-G, low-depression group; LD-G) according to their score on the BAI or BDI-II (separately). In logistic regression analysis, disc hemorrhage, peak intraocular pressure (IOP) and RNFL thickness loss rate were significantly associated with high anxiety (p = 0.017, p = 0.046, p = 0.026). RNFL thinning rate and disc hemorrhage were significant factors associated with anxiety in multivariate models (p = 0.015, p = 0.019). Multivariate linear regression analysis showed a significant positive correlation between the rate of RNFL thickness loss and BAI score (B = 0.058; 95% confidential interval = 0.020–0.097; p = 0.003), and RNFL loss and IOP fluctuation (B = 0.092; 95% confidential interval = 0.030–0.154; p = 0.004). For the depression scale, visual field mean deviation and heart rate variability were significantly associated with high depression in multivariate logistic regression analysis (p = 0.003, p = 0.006). We suggest that anxiety increase the risk of glaucoma progression and they are also associated with IOP profile and disc hemorrhage.Da Young ShinKyoung In JungHae Young Lopilly ParkChan Kee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Da Young Shin Kyoung In Jung Hae Young Lopilly Park Chan Kee Park The effect of anxiety and depression on progression of glaucoma
description	Abstract Glaucoma is considered a chronic disease that requires lifelong management. Chronic diseases are known to be highly associated with psychological disturbances such as depression and anxiety. There have also been many studies on association between anxiety or depression and glaucoma. The majority of these studies explained that the glaucoma diagnosis causes anxiety or depression. However, It is also necessary to evaluate whether the psychological disturbance itself affect glaucoma. Therefore, we investigated the association of anxiety and depression with glaucoma progression, and elucidate mechanisms underlying that. We included 251 eyes with open angle glaucoma who were followed up for at least 2 years in this retrospective case–control study. The Beck Anxiety Inventory (BAI) and Beck Depressive Inventory-II (BDI-II) were used to assess anxiety and depression in glaucoma patients. Patients were classified into groups (high-anxiety group; HA-G, low-anxiety group; LA-G, high-depression group; HD-G, low-depression group; LD-G) according to their score on the BAI or BDI-II (separately). In logistic regression analysis, disc hemorrhage, peak intraocular pressure (IOP) and RNFL thickness loss rate were significantly associated with high anxiety (p = 0.017, p = 0.046, p = 0.026). RNFL thinning rate and disc hemorrhage were significant factors associated with anxiety in multivariate models (p = 0.015, p = 0.019). Multivariate linear regression analysis showed a significant positive correlation between the rate of RNFL thickness loss and BAI score (B = 0.058; 95% confidential interval = 0.020–0.097; p = 0.003), and RNFL loss and IOP fluctuation (B = 0.092; 95% confidential interval = 0.030–0.154; p = 0.004). For the depression scale, visual field mean deviation and heart rate variability were significantly associated with high depression in multivariate logistic regression analysis (p = 0.003, p = 0.006). We suggest that anxiety increase the risk of glaucoma progression and they are also associated with IOP profile and disc hemorrhage.
format	article
author	Da Young Shin Kyoung In Jung Hae Young Lopilly Park Chan Kee Park
author_facet	Da Young Shin Kyoung In Jung Hae Young Lopilly Park Chan Kee Park
author_sort	Da Young Shin
title	The effect of anxiety and depression on progression of glaucoma
title_short	The effect of anxiety and depression on progression of glaucoma
title_full	The effect of anxiety and depression on progression of glaucoma
title_fullStr	The effect of anxiety and depression on progression of glaucoma
title_full_unstemmed	The effect of anxiety and depression on progression of glaucoma
title_sort	effect of anxiety and depression on progression of glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbddf2dc8e4f4fc28ba9822d023b0081
work_keys_str_mv	AT dayoungshin theeffectofanxietyanddepressiononprogressionofglaucoma AT kyounginjung theeffectofanxietyanddepressiononprogressionofglaucoma AT haeyounglopillypark theeffectofanxietyanddepressiononprogressionofglaucoma AT chankeepark theeffectofanxietyanddepressiononprogressionofglaucoma AT dayoungshin effectofanxietyanddepressiononprogressionofglaucoma AT kyounginjung effectofanxietyanddepressiononprogressionofglaucoma AT haeyounglopillypark effectofanxietyanddepressiononprogressionofglaucoma AT chankeepark effectofanxietyanddepressiononprogressionofglaucoma
_version_	1718396625333780480

The effect of anxiety and depression on progression of glaucoma

Ejemplares similares