Senile osteoporosis: Modern view of the problem

The article summarizes the data on senile osteoporosis and presents a clinical case of this disease. The reference sources on peculiarities of bone remodeling in senile osteoporosis are summarized; low bone formation takes place against the background of a pronounced bone resorption. The article als...

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Autores principales:	V.S. Shapovalov, A.S. Musiienko
Formato:	article
Lenguaje:	EN RU UK
Publicado:	Zaslavsky O.Yu. 2021
Materias:	senile osteoporosis, bone remodeling, bone mineral density assessment Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fbde0ba659954ab687d509ba84662b36
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spelling	oai:doaj.org-article:fbde0ba659954ab687d509ba84662b362021-11-12T07:53:09ZSenile osteoporosis: Modern view of the problem2224-15072307-113310.22141/2224-1507.11.3.2021.243049https://doaj.org/article/fbde0ba659954ab687d509ba84662b362021-10-01T00:00:00Zhttp://pjs.zaslavsky.com.ua/article/view/243049https://doaj.org/toc/2224-1507https://doaj.org/toc/2307-1133The article summarizes the data on senile osteoporosis and presents a clinical case of this disease. The reference sources on peculiarities of bone remodeling in senile osteoporosis are summarized; low bone formation takes place against the background of a pronounced bone resorption. The article also presents pathomorphological features of bone tissue remodeling resulting in pronounced impairments of the compact bone, which increase the risk of fracture. Vitamin D plays a significant role in the complex mechanism of senile osteoporosis. The data on the combined effect of vitamin D and parathormone on bone remodeling are summarized. The paper presents data on other cumulative effects of senile osteoporosis development. Against the background of ageing-associated systemic changes, calcium and vitamin D deficiency, increased pro-inflammatory cytokine expression, localized bone disorders develop. An important link to the development of senile osteoporosis is an increased marrow adipose tissue with an intensified adipogenesis, resulting in a decrease of osteoblasts due to the toxic effects of adipokines, reduced differentiation and proliferation of osteoblasts. Age-associated immune-related mechanisms of inflammation, indirectly affecting the bone, are considered. Peculiarities of the senile osteoporosis diagnostics by means of bone mineral density assessment tools are described. Despite the successes achieved in the study of senile osteoporosis development mechanisms, further research is required to explore local and systemic factors affecting bone tissue which are involved in the development of this disease.V.S. ShapovalovA.S. MusiienkoZaslavsky O.Yu.articlesenile osteoporosis, bone remodeling, bone mineral density assessmentMedicine (General)R5-920ENRUUKBolʹ, Sustavy, Pozvonočnik, Vol 11, Iss 3, Pp 118-125 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	senile osteoporosis, bone remodeling, bone mineral density assessment Medicine (General) R5-920
spellingShingle	senile osteoporosis, bone remodeling, bone mineral density assessment Medicine (General) R5-920 V.S. Shapovalov A.S. Musiienko Senile osteoporosis: Modern view of the problem
description	The article summarizes the data on senile osteoporosis and presents a clinical case of this disease. The reference sources on peculiarities of bone remodeling in senile osteoporosis are summarized; low bone formation takes place against the background of a pronounced bone resorption. The article also presents pathomorphological features of bone tissue remodeling resulting in pronounced impairments of the compact bone, which increase the risk of fracture. Vitamin D plays a significant role in the complex mechanism of senile osteoporosis. The data on the combined effect of vitamin D and parathormone on bone remodeling are summarized. The paper presents data on other cumulative effects of senile osteoporosis development. Against the background of ageing-associated systemic changes, calcium and vitamin D deficiency, increased pro-inflammatory cytokine expression, localized bone disorders develop. An important link to the development of senile osteoporosis is an increased marrow adipose tissue with an intensified adipogenesis, resulting in a decrease of osteoblasts due to the toxic effects of adipokines, reduced differentiation and proliferation of osteoblasts. Age-associated immune-related mechanisms of inflammation, indirectly affecting the bone, are considered. Peculiarities of the senile osteoporosis diagnostics by means of bone mineral density assessment tools are described. Despite the successes achieved in the study of senile osteoporosis development mechanisms, further research is required to explore local and systemic factors affecting bone tissue which are involved in the development of this disease.
format	article
author	V.S. Shapovalov A.S. Musiienko
author_facet	V.S. Shapovalov A.S. Musiienko
author_sort	V.S. Shapovalov
title	Senile osteoporosis: Modern view of the problem
title_short	Senile osteoporosis: Modern view of the problem
title_full	Senile osteoporosis: Modern view of the problem
title_fullStr	Senile osteoporosis: Modern view of the problem
title_full_unstemmed	Senile osteoporosis: Modern view of the problem
title_sort	senile osteoporosis: modern view of the problem
publisher	Zaslavsky O.Yu.
publishDate	2021
url	https://doaj.org/article/fbde0ba659954ab687d509ba84662b36
work_keys_str_mv	AT vsshapovalov senileosteoporosismodernviewoftheproblem AT asmusiienko senileosteoporosismodernviewoftheproblem
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Senile osteoporosis: Modern view of the problem

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