Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty

Khaled Alzahrani,1,2 Syarifah-Faiza Dardin,1 Fiona Carley,2 Arun Brahma,2 Debbie Morley,2 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundat...

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Autores principales:	Alzahrani K, Dardin SF, Carley F, Brahma A, Morley D, Hillarby MC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	keratocytes corneal transplantation corneal wound healing keratoconus transparency Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/fbe247d412b74a5e977082d562693a04
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spelling	oai:doaj.org-article:fbe247d412b74a5e977082d562693a042021-12-02T01:46:52ZCorneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty1177-5483https://doaj.org/article/fbe247d412b74a5e977082d562693a042018-03-01T00:00:00Zhttps://www.dovepress.com/corneal-clarity-measurements-in-patients-with-keratoconus-undergoing-e-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Khaled Alzahrani,1,2 Syarifah-Faiza Dardin,1 Fiona Carley,2 Arun Brahma,2 Debbie Morley,2 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK Purpose: To compare the corneal clarity measurement between penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) in patients with keratoconus, using densitometry software for the Oculus Pentacam.Methods: A retrospective comparative study was carried out at Manchester Royal Eye Hospital. Data were collected 12–18 months after corneal transplantation for keratoconus, including postoperative corneal densitometry, best corrected visual acuity (BCVA), central corneal thickness (CCT), and other relevant clinical details.Results: Analysis of 37 keratoconus eyes from 36 patients found there was a significantly higher corneal densitometry measurement after DALK than PK. This was predominantly in the posterior layer of the concentric zone 0–2 mm of the cornea (P=0.0004). A significant correlation was found between postoperative BCVA and corneal densitometry in DALK groups at full thickness (P=0.03). This correlation was seen in the central 0–2 mm (P=0.03) and posterior 0–2 mm (P=0.04) zones. In addition, within the DALK group, a correlation was found between central corneal thickness and densitometry at full thickness 2–6 mm (P=0.007), central 0–2 (P=0.04), central 2–6 mm (P=0.01), and at posterior 2–6 mm (P=0.01) zones.Conclusion: This study showed that corneal densitometry measurement differs depending on the type of corneal transplantation used to treat keratoconus patients. Densitometry may have an important role to play in the final BCVA achieved by patients undergoing corneal transplantation for keratoconus. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the cornea status after the surgery. Keywords: keratocytes, corneal transplantation, corneal wound healing, keratoconus, transparencyAlzahrani KDardin SFCarley FBrahma AMorley DHillarby MCDove Medical Pressarticlekeratocytescorneal transplantationcorneal wound healingkeratoconustransparencyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 577-585 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	keratocytes corneal transplantation corneal wound healing keratoconus transparency Ophthalmology RE1-994
spellingShingle	keratocytes corneal transplantation corneal wound healing keratoconus transparency Ophthalmology RE1-994 Alzahrani K Dardin SF Carley F Brahma A Morley D Hillarby MC Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
description	Khaled Alzahrani,1,2 Syarifah-Faiza Dardin,1 Fiona Carley,2 Arun Brahma,2 Debbie Morley,2 M Chantal Hillarby1 1Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, Manchester, UK; 2Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK Purpose: To compare the corneal clarity measurement between penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) in patients with keratoconus, using densitometry software for the Oculus Pentacam.Methods: A retrospective comparative study was carried out at Manchester Royal Eye Hospital. Data were collected 12–18 months after corneal transplantation for keratoconus, including postoperative corneal densitometry, best corrected visual acuity (BCVA), central corneal thickness (CCT), and other relevant clinical details.Results: Analysis of 37 keratoconus eyes from 36 patients found there was a significantly higher corneal densitometry measurement after DALK than PK. This was predominantly in the posterior layer of the concentric zone 0–2 mm of the cornea (P=0.0004). A significant correlation was found between postoperative BCVA and corneal densitometry in DALK groups at full thickness (P=0.03). This correlation was seen in the central 0–2 mm (P=0.03) and posterior 0–2 mm (P=0.04) zones. In addition, within the DALK group, a correlation was found between central corneal thickness and densitometry at full thickness 2–6 mm (P=0.007), central 0–2 (P=0.04), central 2–6 mm (P=0.01), and at posterior 2–6 mm (P=0.01) zones.Conclusion: This study showed that corneal densitometry measurement differs depending on the type of corneal transplantation used to treat keratoconus patients. Densitometry may have an important role to play in the final BCVA achieved by patients undergoing corneal transplantation for keratoconus. Analysis of Oculus Pentacam images provides an objective evaluation to monitor the cornea status after the surgery. Keywords: keratocytes, corneal transplantation, corneal wound healing, keratoconus, transparency
format	article
author	Alzahrani K Dardin SF Carley F Brahma A Morley D Hillarby MC
author_facet	Alzahrani K Dardin SF Carley F Brahma A Morley D Hillarby MC
author_sort	Alzahrani K
title	Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
title_short	Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
title_full	Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
title_fullStr	Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
title_full_unstemmed	Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
title_sort	corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/fbe247d412b74a5e977082d562693a04
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Corneal clarity measurements in patients with keratoconus undergoing either penetrating or deep anterior lamellar keratoplasty

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