Persistent repair intermediates induce senescence

Cells with damaged DNA can permanently exit the cell cycle during the G2 phase or recover spontaneously entering mitosis. Here the authors reveal that the decision to exit from the cell cycle in G2 is dependent on the presence of repair intermediates associated with homologous recombination.

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Detalles Bibliográficos
Autores principales:	F. M. Feringa, J. A. Raaijmakers, M. A. Hadders, C. Vaarting, L. Macurek, L. Heitink, L. Krenning, R. H. Medema
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbe2d6c421fe40759b25979587a4f76e
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spelling	oai:doaj.org-article:fbe2d6c421fe40759b25979587a4f76e2021-12-02T15:34:40ZPersistent repair intermediates induce senescence10.1038/s41467-018-06308-92041-1723https://doaj.org/article/fbe2d6c421fe40759b25979587a4f76e2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06308-9https://doaj.org/toc/2041-1723Cells with damaged DNA can permanently exit the cell cycle during the G2 phase or recover spontaneously entering mitosis. Here the authors reveal that the decision to exit from the cell cycle in G2 is dependent on the presence of repair intermediates associated with homologous recombination.F. M. FeringaJ. A. RaaijmakersM. A. HaddersC. VaartingL. MacurekL. HeitinkL. KrenningR. H. MedemaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q F. M. Feringa J. A. Raaijmakers M. A. Hadders C. Vaarting L. Macurek L. Heitink L. Krenning R. H. Medema Persistent repair intermediates induce senescence
description	Cells with damaged DNA can permanently exit the cell cycle during the G2 phase or recover spontaneously entering mitosis. Here the authors reveal that the decision to exit from the cell cycle in G2 is dependent on the presence of repair intermediates associated with homologous recombination.
format	article
author	F. M. Feringa J. A. Raaijmakers M. A. Hadders C. Vaarting L. Macurek L. Heitink L. Krenning R. H. Medema
author_facet	F. M. Feringa J. A. Raaijmakers M. A. Hadders C. Vaarting L. Macurek L. Heitink L. Krenning R. H. Medema
author_sort	F. M. Feringa
title	Persistent repair intermediates induce senescence
title_short	Persistent repair intermediates induce senescence
title_full	Persistent repair intermediates induce senescence
title_fullStr	Persistent repair intermediates induce senescence
title_full_unstemmed	Persistent repair intermediates induce senescence
title_sort	persistent repair intermediates induce senescence
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fbe2d6c421fe40759b25979587a4f76e
work_keys_str_mv	AT fmferinga persistentrepairintermediatesinducesenescence AT jaraaijmakers persistentrepairintermediatesinducesenescence AT mahadders persistentrepairintermediatesinducesenescence AT cvaarting persistentrepairintermediatesinducesenescence AT lmacurek persistentrepairintermediatesinducesenescence AT lheitink persistentrepairintermediatesinducesenescence AT lkrenning persistentrepairintermediatesinducesenescence AT rhmedema persistentrepairintermediatesinducesenescence
_version_	1718386817956315136

Persistent repair intermediates induce senescence

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