How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study

The aim of our study was to explore the potential value of metallic (Ag, Cu, and Zn) salts, polymer/metallic nanoparticles, and chlorhexidine (CHX) for improving the antimicrobial activity of calcium hydroxide (CH) against <i>E. faecalis</i> and <i>C. albicans</i>, associated...

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Autores principales:	Kadiatou Sy, Kevimy Agossa, Mickaël Maton, Henry Chijcheapaza-Flores, Bernard Martel, Florence Siepmann, Etienne Deveaux, Nicolas Blanchemain, Christel Neut
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endodontic infections calcium hydroxide chlorhexidine copper silver zinc Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/fbe37b1bede249f1842d00f6d823ba69
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spelling	oai:doaj.org-article:fbe37b1bede249f1842d00f6d823ba692021-11-25T16:23:20ZHow Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study10.3390/antibiotics101113522079-6382https://doaj.org/article/fbe37b1bede249f1842d00f6d823ba692021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1352https://doaj.org/toc/2079-6382The aim of our study was to explore the potential value of metallic (Ag, Cu, and Zn) salts, polymer/metallic nanoparticles, and chlorhexidine (CHX) for improving the antimicrobial activity of calcium hydroxide (CH) against <i>E. faecalis</i> and <i>C. albicans</i>, associated with persistent endodontic infections. A first screening was performed by determining minimum inhibitory/bactericidal concentrations (MIC/MBC). Antimicrobial activity of the CH paste mixed with metallic salts, chitosan or cyclodextrin polymer metallic nanoparticles was compared to the antimicrobial activity of CH paste alone and CH + CHX using a time-kill kinetics assay. The effect of the antimicrobials on the rheological and the key mechanical properties were also examined. Copper and zinc were discarded because of their MIC/MBC values and silver because of its kill time curve profile. Except for a slower setting time after 24 h and a higher weight loss after 1 week of incubation, the mechanical behavior of the CH paste was unaffected by the addition of CHX. Polymeric/metallic nanoparticles failed to potentiate the antimicrobial effect of CH. By contrast, CHX increased this effect and thus could help eradicate <i>E. faecalis</i> associated with persistent root canal infections without altering the desired key physical properties of the CH paste.Kadiatou SyKevimy AgossaMickaël MatonHenry Chijcheapaza-FloresBernard MartelFlorence SiepmannEtienne DeveauxNicolas BlanchemainChristel NeutMDPI AGarticleendodontic infectionscalcium hydroxidechlorhexidinecoppersilverzincTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1352, p 1352 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endodontic infections calcium hydroxide chlorhexidine copper silver zinc Therapeutics. Pharmacology RM1-950
spellingShingle	endodontic infections calcium hydroxide chlorhexidine copper silver zinc Therapeutics. Pharmacology RM1-950 Kadiatou Sy Kevimy Agossa Mickaël Maton Henry Chijcheapaza-Flores Bernard Martel Florence Siepmann Etienne Deveaux Nicolas Blanchemain Christel Neut How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study
description	The aim of our study was to explore the potential value of metallic (Ag, Cu, and Zn) salts, polymer/metallic nanoparticles, and chlorhexidine (CHX) for improving the antimicrobial activity of calcium hydroxide (CH) against <i>E. faecalis</i> and <i>C. albicans</i>, associated with persistent endodontic infections. A first screening was performed by determining minimum inhibitory/bactericidal concentrations (MIC/MBC). Antimicrobial activity of the CH paste mixed with metallic salts, chitosan or cyclodextrin polymer metallic nanoparticles was compared to the antimicrobial activity of CH paste alone and CH + CHX using a time-kill kinetics assay. The effect of the antimicrobials on the rheological and the key mechanical properties were also examined. Copper and zinc were discarded because of their MIC/MBC values and silver because of its kill time curve profile. Except for a slower setting time after 24 h and a higher weight loss after 1 week of incubation, the mechanical behavior of the CH paste was unaffected by the addition of CHX. Polymeric/metallic nanoparticles failed to potentiate the antimicrobial effect of CH. By contrast, CHX increased this effect and thus could help eradicate <i>E. faecalis</i> associated with persistent root canal infections without altering the desired key physical properties of the CH paste.
format	article
author	Kadiatou Sy Kevimy Agossa Mickaël Maton Henry Chijcheapaza-Flores Bernard Martel Florence Siepmann Etienne Deveaux Nicolas Blanchemain Christel Neut
author_facet	Kadiatou Sy Kevimy Agossa Mickaël Maton Henry Chijcheapaza-Flores Bernard Martel Florence Siepmann Etienne Deveaux Nicolas Blanchemain Christel Neut
author_sort	Kadiatou Sy
title	How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study
title_short	How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study
title_full	How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study
title_fullStr	How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study
title_full_unstemmed	How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study
title_sort	how adding chlorhexidine or metallic nanoparticles affects the antimicrobial performance of calcium hydroxide paste as an intracanal medication: an in vitro study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fbe37b1bede249f1842d00f6d823ba69
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How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study

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