GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors.

GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors.

<h4>Background</h4>Müller cell gliosis occurs in various retinal pathologies regardless of the underlying cellular defect. Because activated Müller glial cells span the entire retina and align areas of injury, they are ideal targets for therapeutic strategies, including gene therapy.<...

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Main Authors: Wendy M Aartsen, Koen W R van Cleef, Lucie P Pellissier, Robert M Hoek, Rogier M Vos, Bas Blits, Erich M E Ehlert, Kamaljit S Balaggan, Robin R Ali, Joost Verhaagen, Jan Wijnholds
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2010
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/fbe4eb2ddd3748f092d1484bcd58d2f2
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