Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy

Promising results of cancer therapies in transplant tumor models often fail to predict efficacy in clinical trials. Here the authors show that, while transplant tumors are cured by radiotherapy and PD-1 blockade, autochthonous sarcomas are resistant to the identical treatment, recapitulating the imm...

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Autores principales:	Amy J. Wisdom, Yvonne M. Mowery, Cierra S. Hong, Jonathon E. Himes, Barzin Y. Nabet, Xiaodi Qin, Dadong Zhang, Lan Chen, Hélène Fradin, Rutulkumar Patel, Alex M. Bassil, Eric S. Muise, Daniel A. King, Eric S. Xu, David J. Carpenter, Collin L. Kent, Kimberly S. Smythe, Nerissa T. Williams, Lixia Luo, Yan Ma, Ash A. Alizadeh, Kouros Owzar, Maximilian Diehn, Todd Bradley, David G. Kirsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbe59ef20fbb4396b5ce9b48beedf7a7
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spelling	oai:doaj.org-article:fbe59ef20fbb4396b5ce9b48beedf7a72021-12-02T14:16:31ZSingle cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy10.1038/s41467-020-19917-02041-1723https://doaj.org/article/fbe59ef20fbb4396b5ce9b48beedf7a72020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19917-0https://doaj.org/toc/2041-1723Promising results of cancer therapies in transplant tumor models often fail to predict efficacy in clinical trials. Here the authors show that, while transplant tumors are cured by radiotherapy and PD-1 blockade, autochthonous sarcomas are resistant to the identical treatment, recapitulating the immune landscape and resistance to checkpoint blockade observed in most sarcoma patients.Amy J. WisdomYvonne M. MoweryCierra S. HongJonathon E. HimesBarzin Y. NabetXiaodi QinDadong ZhangLan ChenHélène FradinRutulkumar PatelAlex M. BassilEric S. MuiseDaniel A. KingEric S. XuDavid J. CarpenterCollin L. KentKimberly S. SmytheNerissa T. WilliamsLixia LuoYan MaAsh A. AlizadehKouros OwzarMaximilian DiehnTodd BradleyDavid G. KirschNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy J. Wisdom Yvonne M. Mowery Cierra S. Hong Jonathon E. Himes Barzin Y. Nabet Xiaodi Qin Dadong Zhang Lan Chen Hélène Fradin Rutulkumar Patel Alex M. Bassil Eric S. Muise Daniel A. King Eric S. Xu David J. Carpenter Collin L. Kent Kimberly S. Smythe Nerissa T. Williams Lixia Luo Yan Ma Ash A. Alizadeh Kouros Owzar Maximilian Diehn Todd Bradley David G. Kirsch Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
description	Promising results of cancer therapies in transplant tumor models often fail to predict efficacy in clinical trials. Here the authors show that, while transplant tumors are cured by radiotherapy and PD-1 blockade, autochthonous sarcomas are resistant to the identical treatment, recapitulating the immune landscape and resistance to checkpoint blockade observed in most sarcoma patients.
format	article
author	Amy J. Wisdom Yvonne M. Mowery Cierra S. Hong Jonathon E. Himes Barzin Y. Nabet Xiaodi Qin Dadong Zhang Lan Chen Hélène Fradin Rutulkumar Patel Alex M. Bassil Eric S. Muise Daniel A. King Eric S. Xu David J. Carpenter Collin L. Kent Kimberly S. Smythe Nerissa T. Williams Lixia Luo Yan Ma Ash A. Alizadeh Kouros Owzar Maximilian Diehn Todd Bradley David G. Kirsch
author_facet	Amy J. Wisdom Yvonne M. Mowery Cierra S. Hong Jonathon E. Himes Barzin Y. Nabet Xiaodi Qin Dadong Zhang Lan Chen Hélène Fradin Rutulkumar Patel Alex M. Bassil Eric S. Muise Daniel A. King Eric S. Xu David J. Carpenter Collin L. Kent Kimberly S. Smythe Nerissa T. Williams Lixia Luo Yan Ma Ash A. Alizadeh Kouros Owzar Maximilian Diehn Todd Bradley David G. Kirsch
author_sort	Amy J. Wisdom
title	Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
title_short	Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
title_full	Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
title_fullStr	Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
title_full_unstemmed	Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
title_sort	single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fbe59ef20fbb4396b5ce9b48beedf7a7
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Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy

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