Identification of a TGF-β/SMAD/lnc-UTGF positive feedback loop and its role in hepatoma metastasis

Abstract Aberrant activation of the TGF-β/SMAD signaling pathway is often observed in hepatocellular carcinoma (HCC). Whether lncRNA regulates the TGF-β/SMAD signaling remains largely unknown. Here, we identified an oncogenic lncRNA that was upregulated in HCC and was transcriptionally induced by TG...

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Autores principales: Meng-Zhi Wu, Yi-chuan Yuan, Bi-Yu Huang, Jin-Xi Chen, Bin-Kui Li, Jian-Hong Fang, Shi-Mei Zhuang
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
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Acceso en línea:https://doaj.org/article/fbe62e45283a4e7e874c2f402866d1ea
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