DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Trex1 is an exonuclease that degrades cytosolic DNA and has been associated with modulation of interferon responses in autoimmunity and viral infections. Here, the authors show that Trex1 attenuates the immunogenicity of cancer cells treated with high radiation doses by degrading cytosolic DNA and p...

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Autores principales:	Claire Vanpouille-Box, Amandine Alard, Molykutty J. Aryankalayil, Yasmeen Sarfraz, Julie M. Diamond, Robert J. Schneider, Giorgio Inghirami, C. Norman Coleman, Silvia C. Formenti, Sandra Demaria
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbe7810370734d60b0bb36cf8cb9767e
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spelling	oai:doaj.org-article:fbe7810370734d60b0bb36cf8cb9767e2021-12-02T17:06:12ZDNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity10.1038/ncomms156182041-1723https://doaj.org/article/fbe7810370734d60b0bb36cf8cb9767e2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15618https://doaj.org/toc/2041-1723Trex1 is an exonuclease that degrades cytosolic DNA and has been associated with modulation of interferon responses in autoimmunity and viral infections. Here, the authors show that Trex1 attenuates the immunogenicity of cancer cells treated with high radiation doses by degrading cytosolic DNA and preventing the activation of interferon response.Claire Vanpouille-BoxAmandine AlardMolykutty J. AryankalayilYasmeen SarfrazJulie M. DiamondRobert J. SchneiderGiorgio InghiramiC. Norman ColemanSilvia C. FormentiSandra DemariaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claire Vanpouille-Box Amandine Alard Molykutty J. Aryankalayil Yasmeen Sarfraz Julie M. Diamond Robert J. Schneider Giorgio Inghirami C. Norman Coleman Silvia C. Formenti Sandra Demaria DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
description	Trex1 is an exonuclease that degrades cytosolic DNA and has been associated with modulation of interferon responses in autoimmunity and viral infections. Here, the authors show that Trex1 attenuates the immunogenicity of cancer cells treated with high radiation doses by degrading cytosolic DNA and preventing the activation of interferon response.
format	article
author	Claire Vanpouille-Box Amandine Alard Molykutty J. Aryankalayil Yasmeen Sarfraz Julie M. Diamond Robert J. Schneider Giorgio Inghirami C. Norman Coleman Silvia C. Formenti Sandra Demaria
author_facet	Claire Vanpouille-Box Amandine Alard Molykutty J. Aryankalayil Yasmeen Sarfraz Julie M. Diamond Robert J. Schneider Giorgio Inghirami C. Norman Coleman Silvia C. Formenti Sandra Demaria
author_sort	Claire Vanpouille-Box
title	DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
title_short	DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
title_full	DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
title_fullStr	DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
title_full_unstemmed	DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity
title_sort	dna exonuclease trex1 regulates radiotherapy-induced tumour immunogenicity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fbe7810370734d60b0bb36cf8cb9767e
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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

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