Regional grey and white matter changes in heavy male smokers.

Cigarette smoking is highly prevalent in the general population but the effects of chronic smoking on brain structures are still unclear. Previous studies have found mixed results regarding regional grey matter abnormalities in smokers. To characterize both grey and white matter changes in heavy mal...

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Autores principales:	Rongjun Yu, Liyan Zhao, Lin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbe88f81395f48b48c867ed8ee33a58b
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spelling	oai:doaj.org-article:fbe88f81395f48b48c867ed8ee33a58b2021-11-18T07:34:53ZRegional grey and white matter changes in heavy male smokers.1932-620310.1371/journal.pone.0027440https://doaj.org/article/fbe88f81395f48b48c867ed8ee33a58b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22076160/?tool=EBIhttps://doaj.org/toc/1932-6203Cigarette smoking is highly prevalent in the general population but the effects of chronic smoking on brain structures are still unclear. Previous studies have found mixed results regarding regional grey matter abnormalities in smokers. To characterize both grey and white matter changes in heavy male smokers, we investigated 16 heavy smokers and 16 matched healthy controls, using both univariate voxel-based morphometry (VBM) and multivariate pattern classification analysis. Compared with controls, heavy smokers exhibited smaller grey matter volume in cerebellum, as well as larger white matter volume in putamen, anterior and middle cingulate cortex. Further, the spatial patterns of grey matter or white matter both discriminated smokers from controls in these regions as well as in other brain regions. Our findings demonstrated volume abnormalities not only in the grey matter but also in the white matter in heavy male smokers. The multivariate analysis suggests that chronic smoking may be associated with volume alternations in broader brain regions than those identified in VBM analysis. These results may better our understanding of the neurobiological consequence of smoking and inform smoking treatment.Rongjun YuLiyan ZhaoLin LuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27440 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rongjun Yu Liyan Zhao Lin Lu Regional grey and white matter changes in heavy male smokers.
description	Cigarette smoking is highly prevalent in the general population but the effects of chronic smoking on brain structures are still unclear. Previous studies have found mixed results regarding regional grey matter abnormalities in smokers. To characterize both grey and white matter changes in heavy male smokers, we investigated 16 heavy smokers and 16 matched healthy controls, using both univariate voxel-based morphometry (VBM) and multivariate pattern classification analysis. Compared with controls, heavy smokers exhibited smaller grey matter volume in cerebellum, as well as larger white matter volume in putamen, anterior and middle cingulate cortex. Further, the spatial patterns of grey matter or white matter both discriminated smokers from controls in these regions as well as in other brain regions. Our findings demonstrated volume abnormalities not only in the grey matter but also in the white matter in heavy male smokers. The multivariate analysis suggests that chronic smoking may be associated with volume alternations in broader brain regions than those identified in VBM analysis. These results may better our understanding of the neurobiological consequence of smoking and inform smoking treatment.
format	article
author	Rongjun Yu Liyan Zhao Lin Lu
author_facet	Rongjun Yu Liyan Zhao Lin Lu
author_sort	Rongjun Yu
title	Regional grey and white matter changes in heavy male smokers.
title_short	Regional grey and white matter changes in heavy male smokers.
title_full	Regional grey and white matter changes in heavy male smokers.
title_fullStr	Regional grey and white matter changes in heavy male smokers.
title_full_unstemmed	Regional grey and white matter changes in heavy male smokers.
title_sort	regional grey and white matter changes in heavy male smokers.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/fbe88f81395f48b48c867ed8ee33a58b
work_keys_str_mv	AT rongjunyu regionalgreyandwhitematterchangesinheavymalesmokers AT liyanzhao regionalgreyandwhitematterchangesinheavymalesmokers AT linlu regionalgreyandwhitematterchangesinheavymalesmokers
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Regional grey and white matter changes in heavy male smokers.

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