Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking

Sentinel pelvic lymph node dissection (sPLND) enables the targeted removal of lymph nodes (LNs) bearing the highest metastasis risk. In prostate cancer (PCa), sPLND alone or combined with extended PLND (ePLND) reveals more LN metastases along with detecting sentinel LNs (SLNs) outside the convention...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Svenja Engels, Bianca Michalik, Luca-Marie Meyer, Lena Nemitz, Friedhelm Wawroschek, Alexander Winter
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate cancer sentinel lymph node lymphadenectomy metastases superparamagnetic iron oxide nanoparticles radioisotopes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fbe89264a0ae46c0a04fdd0fd7bb21fa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fbe89264a0ae46c0a04fdd0fd7bb21fa
record_format	dspace
spelling	oai:doaj.org-article:fbe89264a0ae46c0a04fdd0fd7bb21fa2021-11-25T17:04:26ZMagnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking10.3390/cancers132258212072-6694https://doaj.org/article/fbe89264a0ae46c0a04fdd0fd7bb21fa2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5821https://doaj.org/toc/2072-6694Sentinel pelvic lymph node dissection (sPLND) enables the targeted removal of lymph nodes (LNs) bearing the highest metastasis risk. In prostate cancer (PCa), sPLND alone or combined with extended PLND (ePLND) reveals more LN metastases along with detecting sentinel LNs (SLNs) outside the conventional ePLND template. To overcome the disadvantages of radioisotope-guided sPLND in PCa treatment, magnetometer-guided sPLND applying superparamagnetic iron oxide nanoparticles as a tracer was established. This retrospective study compared the nodal staging ability between magnetometer- and radioisotope-guided sPLNDs. We analyzed data of PCa patients undergoing radical prostatectomy and magnetometer- (848 patients, 2015–2021) or radioisotope-guided (2092 patients, 2006–2015) sPLND. To reduce heterogeneity among cohorts, we performed propensity score matching and compared data considering sentinel nomogram-based probabilities for LN involvement (LNI). Magnetometer- and radioisotope-guided sPLNDs had SLN detection rates of 98.12% and 98.09%, respectively; the former detected more SLNs per patient. The LNI rates matched nomogram-based predictions in both techniques equally well. Approximately 7% of LN metastases were detected outside the conventional ePLND template. Thus, we confirmed the reliability of magnetometer-guided sPLND in nodal staging, with results comparable with or better than radioisotope-guided sPLND. Our findings highlight the importance of the sentinel technique for detecting LN metastases in PCa.Svenja EngelsBianca MichalikLuca-Marie MeyerLena NemitzFriedhelm WawroschekAlexander WinterMDPI AGarticleprostate cancersentinel lymph nodelymphadenectomymetastasessuperparamagnetic iron oxide nanoparticlesradioisotopesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5821, p 5821 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer sentinel lymph node lymphadenectomy metastases superparamagnetic iron oxide nanoparticles radioisotopes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	prostate cancer sentinel lymph node lymphadenectomy metastases superparamagnetic iron oxide nanoparticles radioisotopes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Svenja Engels Bianca Michalik Luca-Marie Meyer Lena Nemitz Friedhelm Wawroschek Alexander Winter Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking
description	Sentinel pelvic lymph node dissection (sPLND) enables the targeted removal of lymph nodes (LNs) bearing the highest metastasis risk. In prostate cancer (PCa), sPLND alone or combined with extended PLND (ePLND) reveals more LN metastases along with detecting sentinel LNs (SLNs) outside the conventional ePLND template. To overcome the disadvantages of radioisotope-guided sPLND in PCa treatment, magnetometer-guided sPLND applying superparamagnetic iron oxide nanoparticles as a tracer was established. This retrospective study compared the nodal staging ability between magnetometer- and radioisotope-guided sPLNDs. We analyzed data of PCa patients undergoing radical prostatectomy and magnetometer- (848 patients, 2015–2021) or radioisotope-guided (2092 patients, 2006–2015) sPLND. To reduce heterogeneity among cohorts, we performed propensity score matching and compared data considering sentinel nomogram-based probabilities for LN involvement (LNI). Magnetometer- and radioisotope-guided sPLNDs had SLN detection rates of 98.12% and 98.09%, respectively; the former detected more SLNs per patient. The LNI rates matched nomogram-based predictions in both techniques equally well. Approximately 7% of LN metastases were detected outside the conventional ePLND template. Thus, we confirmed the reliability of magnetometer-guided sPLND in nodal staging, with results comparable with or better than radioisotope-guided sPLND. Our findings highlight the importance of the sentinel technique for detecting LN metastases in PCa.
format	article
author	Svenja Engels Bianca Michalik Luca-Marie Meyer Lena Nemitz Friedhelm Wawroschek Alexander Winter
author_facet	Svenja Engels Bianca Michalik Luca-Marie Meyer Lena Nemitz Friedhelm Wawroschek Alexander Winter
author_sort	Svenja Engels
title	Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking
title_short	Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking
title_full	Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking
title_fullStr	Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking
title_full_unstemmed	Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking
title_sort	magnetometer-guided sentinel lymph node dissection in prostate cancer: rate of lymph node involvement compared with radioisotope marking
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fbe89264a0ae46c0a04fdd0fd7bb21fa
work_keys_str_mv	AT svenjaengels magnetometerguidedsentinellymphnodedissectioninprostatecancerrateoflymphnodeinvolvementcomparedwithradioisotopemarking AT biancamichalik magnetometerguidedsentinellymphnodedissectioninprostatecancerrateoflymphnodeinvolvementcomparedwithradioisotopemarking AT lucamariemeyer magnetometerguidedsentinellymphnodedissectioninprostatecancerrateoflymphnodeinvolvementcomparedwithradioisotopemarking AT lenanemitz magnetometerguidedsentinellymphnodedissectioninprostatecancerrateoflymphnodeinvolvementcomparedwithradioisotopemarking AT friedhelmwawroschek magnetometerguidedsentinellymphnodedissectioninprostatecancerrateoflymphnodeinvolvementcomparedwithradioisotopemarking AT alexanderwinter magnetometerguidedsentinellymphnodedissectioninprostatecancerrateoflymphnodeinvolvementcomparedwithradioisotopemarking
_version_	1718412751636791296

Magnetometer-Guided Sentinel Lymph Node Dissection in Prostate Cancer: Rate of Lymph Node Involvement Compared with Radioisotope Marking

Ejemplares similares