Serum TSLP is a potential biomarker of psoriasis vulgaris activity

Mohamed Ibrahim El-Ghareeb,1 Afaf Helmy,1 Sally Al Kazzaz,2 Hanan Samir31Department of Dermatology, Zagazig University, Zagazig, Egypt; 2Dermatology, Zagazig General Hospital, Zagazig, Egypt; 3Clinical Pathology, Zagazig University, Zagazig, EgyptBackground: The proallergic cytokine, thymic stromal...

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Autores principales:	El-Ghareeb MI, Helmy A, Al Kazzaz S, Samir H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	TSLP Psoriasis vulgaris Serum biomarker Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/fbed66a5109445f1a20f1c8961964441
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spelling	oai:doaj.org-article:fbed66a5109445f1a20f1c89619644412021-12-02T06:30:20ZSerum TSLP is a potential biomarker of psoriasis vulgaris activity2230-326Xhttps://doaj.org/article/fbed66a5109445f1a20f1c89619644412019-07-01T00:00:00Zhttps://www.dovepress.com/serum-tslp-is-a-potential-biomarker-of-psoriasis-vulgaris-activity-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XMohamed Ibrahim El-Ghareeb,1 Afaf Helmy,1 Sally Al Kazzaz,2 Hanan Samir31Department of Dermatology, Zagazig University, Zagazig, Egypt; 2Dermatology, Zagazig General Hospital, Zagazig, Egypt; 3Clinical Pathology, Zagazig University, Zagazig, EgyptBackground: The proallergic cytokine, thymic stromal lymphopoietin (TSLP) may synergize with T cell–derived CD40 ligand (CD40L) to allow IL-23 production in patients with psoriasis. IL-23 is a central cytokine that mediates the inappropriate immune reaction in patients with psoriasis.Objective: The aim of the study was to correlate serum level of TSLP with psoriasis severity.Methods: The study was carried out on 53 patients with psoriasis. They were divided into mild, moderate, and severe according to PASI score. The patients’ ages ranged from 10 to 62 years. The patients included 29 males and 24 females. A total of 53 healthy subjects with matched age and sex served as control group. Blood samples were collected from the venous blood of the patients and control subjects then the serum was separated. The serum samples were immediately frozen at -20°C. Serum TSLP was measured by Sandwich Enzyme–linked Immunosorbant Assay (ELISA).Results: There was a statistically very highly significant increase (p<0.001) in serum TSLP levels among the case group (1042.7±812.93) compared to the control group (314.21±220.78). There was also a statistically very highly significant increase (p<0.001) in serum TSLP levels with increased psoriasis severity estimated by PASI score.Conclusion: In this study, we found that serum TSLP is elevated in psoriasis patients and is correlated with disease severity.Keywords: TSLP, psoriasis vulgaris, serum biomarkerEl-Ghareeb MIHelmy AAl Kazzaz SSamir HDove Medical PressarticleTSLPPsoriasis vulgarisSerum biomarkerDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 9, Pp 59-63 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	TSLP Psoriasis vulgaris Serum biomarker Dermatology RL1-803
spellingShingle	TSLP Psoriasis vulgaris Serum biomarker Dermatology RL1-803 El-Ghareeb MI Helmy A Al Kazzaz S Samir H Serum TSLP is a potential biomarker of psoriasis vulgaris activity
description	Mohamed Ibrahim El-Ghareeb,1 Afaf Helmy,1 Sally Al Kazzaz,2 Hanan Samir31Department of Dermatology, Zagazig University, Zagazig, Egypt; 2Dermatology, Zagazig General Hospital, Zagazig, Egypt; 3Clinical Pathology, Zagazig University, Zagazig, EgyptBackground: The proallergic cytokine, thymic stromal lymphopoietin (TSLP) may synergize with T cell–derived CD40 ligand (CD40L) to allow IL-23 production in patients with psoriasis. IL-23 is a central cytokine that mediates the inappropriate immune reaction in patients with psoriasis.Objective: The aim of the study was to correlate serum level of TSLP with psoriasis severity.Methods: The study was carried out on 53 patients with psoriasis. They were divided into mild, moderate, and severe according to PASI score. The patients’ ages ranged from 10 to 62 years. The patients included 29 males and 24 females. A total of 53 healthy subjects with matched age and sex served as control group. Blood samples were collected from the venous blood of the patients and control subjects then the serum was separated. The serum samples were immediately frozen at -20°C. Serum TSLP was measured by Sandwich Enzyme–linked Immunosorbant Assay (ELISA).Results: There was a statistically very highly significant increase (p<0.001) in serum TSLP levels among the case group (1042.7±812.93) compared to the control group (314.21±220.78). There was also a statistically very highly significant increase (p<0.001) in serum TSLP levels with increased psoriasis severity estimated by PASI score.Conclusion: In this study, we found that serum TSLP is elevated in psoriasis patients and is correlated with disease severity.Keywords: TSLP, psoriasis vulgaris, serum biomarker
format	article
author	El-Ghareeb MI Helmy A Al Kazzaz S Samir H
author_facet	El-Ghareeb MI Helmy A Al Kazzaz S Samir H
author_sort	El-Ghareeb MI
title	Serum TSLP is a potential biomarker of psoriasis vulgaris activity
title_short	Serum TSLP is a potential biomarker of psoriasis vulgaris activity
title_full	Serum TSLP is a potential biomarker of psoriasis vulgaris activity
title_fullStr	Serum TSLP is a potential biomarker of psoriasis vulgaris activity
title_full_unstemmed	Serum TSLP is a potential biomarker of psoriasis vulgaris activity
title_sort	serum tslp is a potential biomarker of psoriasis vulgaris activity
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/fbed66a5109445f1a20f1c8961964441
work_keys_str_mv	AT elghareebmi serumtslpisapotentialbiomarkerofpsoriasisvulgarisactivity AT helmya serumtslpisapotentialbiomarkerofpsoriasisvulgarisactivity AT alkazzazs serumtslpisapotentialbiomarkerofpsoriasisvulgarisactivity AT samirh serumtslpisapotentialbiomarkerofpsoriasisvulgarisactivity
_version_	1718399911677919232

Serum TSLP is a potential biomarker of psoriasis vulgaris activity

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