Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver

Obesity can be associated with an increased risk of metabolic complications. Here, the authors show that adipocyte-specific ablation of the phosphatase PHLPP2 improves glucose homeostasis in high-fat diet fed obese mice, and that this may be due at least in part to PHLPP2 dephosphorylation of HSL.

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Autores principales:	KyeongJin Kim, Jin Ku Kang, Young Hoon Jung, Sang Bae Lee, Raffaela Rametta, Paola Dongiovanni, Luca Valenti, Utpal B. Pajvani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbedf8ee43a14e308e77f09b74b4c302
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spelling	oai:doaj.org-article:fbedf8ee43a14e308e77f09b74b4c3022021-12-02T17:04:30ZAdipocyte PHLPP2 inhibition prevents obesity-induced fatty liver10.1038/s41467-021-22106-22041-1723https://doaj.org/article/fbedf8ee43a14e308e77f09b74b4c3022021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22106-2https://doaj.org/toc/2041-1723Obesity can be associated with an increased risk of metabolic complications. Here, the authors show that adipocyte-specific ablation of the phosphatase PHLPP2 improves glucose homeostasis in high-fat diet fed obese mice, and that this may be due at least in part to PHLPP2 dephosphorylation of HSL.KyeongJin KimJin Ku KangYoung Hoon JungSang Bae LeeRaffaela RamettaPaola DongiovanniLuca ValentiUtpal B. PajvaniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q KyeongJin Kim Jin Ku Kang Young Hoon Jung Sang Bae Lee Raffaela Rametta Paola Dongiovanni Luca Valenti Utpal B. Pajvani Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
description	Obesity can be associated with an increased risk of metabolic complications. Here, the authors show that adipocyte-specific ablation of the phosphatase PHLPP2 improves glucose homeostasis in high-fat diet fed obese mice, and that this may be due at least in part to PHLPP2 dephosphorylation of HSL.
format	article
author	KyeongJin Kim Jin Ku Kang Young Hoon Jung Sang Bae Lee Raffaela Rametta Paola Dongiovanni Luca Valenti Utpal B. Pajvani
author_facet	KyeongJin Kim Jin Ku Kang Young Hoon Jung Sang Bae Lee Raffaela Rametta Paola Dongiovanni Luca Valenti Utpal B. Pajvani
author_sort	KyeongJin Kim
title	Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
title_short	Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
title_full	Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
title_fullStr	Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
title_full_unstemmed	Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
title_sort	adipocyte phlpp2 inhibition prevents obesity-induced fatty liver
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbedf8ee43a14e308e77f09b74b4c302
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Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver

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