Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver
Obesity can be associated with an increased risk of metabolic complications. Here, the authors show that adipocyte-specific ablation of the phosphatase PHLPP2 improves glucose homeostasis in high-fat diet fed obese mice, and that this may be due at least in part to PHLPP2 dephosphorylation of HSL.
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Autores principales: | KyeongJin Kim, Jin Ku Kang, Young Hoon Jung, Sang Bae Lee, Raffaela Rametta, Paola Dongiovanni, Luca Valenti, Utpal B. Pajvani |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/fbedf8ee43a14e308e77f09b74b4c302 |
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