Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature

Giant cell tumor of soft tissue (GCT-ST) is an extremely rare tumor that is similar in morphology and immunohistochemistry to giant cell tumor of the bone. Almost 80% of these tumors occur in the upper and lower extremities, and the breast is a very rare location. Here, we report a case of a 65-year...

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Autores principales:	Wenxiang Zhang, Xiangyi Kong, Yihang Qi, Xiangyu Wang, Qiang Liu, Yi Fang, Yan Song, Jing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	giant cell tumor of soft tissue breast tumor diagnosis treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fbeecf76a77445ebbb02afeaf970ccf5
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spelling	oai:doaj.org-article:fbeecf76a77445ebbb02afeaf970ccf52021-11-05T11:23:09ZPrimary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature2234-943X10.3389/fonc.2021.638237https://doaj.org/article/fbeecf76a77445ebbb02afeaf970ccf52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.638237/fullhttps://doaj.org/toc/2234-943XGiant cell tumor of soft tissue (GCT-ST) is an extremely rare tumor that is similar in morphology and immunohistochemistry to giant cell tumor of the bone. Almost 80% of these tumors occur in the upper and lower extremities, and the breast is a very rare location. Here, we report a case of a 65-year-old female patient with a small mobile palpable lump in the left breast. Although the left breast tumor was considered malignant on preoperative imaging, no evidence of malignant tumor was found by ultrasound-guided core needle biopsy (CNB). Subsequently, the left breast tumor was confirmed as a malignant tumor by intraoperative rapid pathological examination. The initial treatment of the tumor was wide local excision and sentinel lymph node biopsy, and it was confirmed to be GCT-ST by histopathology and immunohistochemistry. Despite surgical treatment achieving clear surgical margins, the patient experienced lung metastases within a year of her initial treatment. Fortunately, the patient underwent surgical treatment of lung metastases, and at the last follow-up, the patient was still alive. This is the first case of a primary soft tissue tumor of the breast that has undergone surgical intervention after lung metastasis. This case report highlights the complexity of the clinical diagnosis and treatment of GCT-ST arising from the breast. Surgery may be another good treatment when the patient develops lung metastases.Wenxiang ZhangXiangyi KongYihang QiXiangyu WangQiang LiuYi FangYan SongJing WangFrontiers Media S.A.articlegiant cell tumor of soft tissuebreast tumordiagnosistreatmentprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	giant cell tumor of soft tissue breast tumor diagnosis treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	giant cell tumor of soft tissue breast tumor diagnosis treatment prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wenxiang Zhang Xiangyi Kong Yihang Qi Xiangyu Wang Qiang Liu Yi Fang Yan Song Jing Wang Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature
description	Giant cell tumor of soft tissue (GCT-ST) is an extremely rare tumor that is similar in morphology and immunohistochemistry to giant cell tumor of the bone. Almost 80% of these tumors occur in the upper and lower extremities, and the breast is a very rare location. Here, we report a case of a 65-year-old female patient with a small mobile palpable lump in the left breast. Although the left breast tumor was considered malignant on preoperative imaging, no evidence of malignant tumor was found by ultrasound-guided core needle biopsy (CNB). Subsequently, the left breast tumor was confirmed as a malignant tumor by intraoperative rapid pathological examination. The initial treatment of the tumor was wide local excision and sentinel lymph node biopsy, and it was confirmed to be GCT-ST by histopathology and immunohistochemistry. Despite surgical treatment achieving clear surgical margins, the patient experienced lung metastases within a year of her initial treatment. Fortunately, the patient underwent surgical treatment of lung metastases, and at the last follow-up, the patient was still alive. This is the first case of a primary soft tissue tumor of the breast that has undergone surgical intervention after lung metastasis. This case report highlights the complexity of the clinical diagnosis and treatment of GCT-ST arising from the breast. Surgery may be another good treatment when the patient develops lung metastases.
format	article
author	Wenxiang Zhang Xiangyi Kong Yihang Qi Xiangyu Wang Qiang Liu Yi Fang Yan Song Jing Wang
author_facet	Wenxiang Zhang Xiangyi Kong Yihang Qi Xiangyu Wang Qiang Liu Yi Fang Yan Song Jing Wang
author_sort	Wenxiang Zhang
title	Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature
title_short	Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature
title_full	Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature
title_fullStr	Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature
title_full_unstemmed	Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature
title_sort	primary giant cell tumor of the breast with pulmonary metastasis: a case report and review of the literature
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fbeecf76a77445ebbb02afeaf970ccf5
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Primary Giant Cell Tumor of the Breast With Pulmonary Metastasis: A Case Report and Review of the Literature

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