New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus associated with the progressive deterioration of renal function. Although microalbuminuria is considered as a gold standard for DN diagnosis, it has limited predictive powers and specificity as a diagnostic tool for the early st...
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Endocrinology Research Centre
2017
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oai:doaj.org-article:fbf28cb2b829420d9af6687732f3627a2021-11-14T09:00:21ZNew insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets2072-03512072-037810.14341/DM8237https://doaj.org/article/fbf28cb2b829420d9af6687732f3627a2017-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8237https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Diabetic nephropathy (DN) is a severe complication of diabetes mellitus associated with the progressive deterioration of renal function. Although microalbuminuria is considered as a gold standard for DN diagnosis, it has limited predictive powers and specificity as a diagnostic tool for the early stage of DN. Therefore, new biomarkers are required for the early detection of DN. Studies using in vitro and in vivo models of DN have revealed an important role of microRNAs (miRNAs), short non-coding RNAs that modulate physiological and pathological processes by inhibiting target gene expression, in DN development. Recent studies have shown that the dysregulation of miRNAs, which is associated with the key features of DN, such as the mesangial expansion and accumulation of extracellular matrix proteins, is related to fibrosis and glomerular dysfunction. Thus, the up- and downregulation of miRNA expression in the renal tissue or biological fluids, including urine, may represent new biomarkers for the diagnosis and monitoring of DN progression. In this review, we highlight the significance of miRNAs as biomarkers for the early detection of DN and emphasise their potential role as a therapeutic target.Elena Sergeevna KamyshovaIrina Nikolaevna BobkovaIrina Mikhailovna KutyrinaEndocrinology Research Centrearticlediabetic nephropathybiomarkermirnaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 1, Pp 42-50 (2017) |
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DOAJ |
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EN RU |
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diabetic nephropathy biomarker mirna Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
diabetic nephropathy biomarker mirna Nutritional diseases. Deficiency diseases RC620-627 Elena Sergeevna Kamyshova Irina Nikolaevna Bobkova Irina Mikhailovna Kutyrina New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets |
| description |
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus associated with the progressive deterioration of renal function. Although microalbuminuria is considered as a gold standard for DN diagnosis, it has limited predictive powers and specificity as a diagnostic tool for the early stage of DN. Therefore, new biomarkers are required for the early detection of DN. Studies using in vitro and in vivo models of DN have revealed an important role of microRNAs (miRNAs), short non-coding RNAs that modulate physiological and pathological processes by inhibiting target gene expression, in DN development. Recent studies have shown that the dysregulation of miRNAs, which is associated with the key features of DN, such as the mesangial expansion and accumulation of extracellular matrix proteins, is related to fibrosis and glomerular dysfunction. Thus, the up- and downregulation of miRNA expression in the renal tissue or biological fluids, including urine, may represent new biomarkers for the diagnosis and monitoring of DN progression. In this review, we highlight the significance of miRNAs as biomarkers for the early detection of DN and emphasise their potential role as a therapeutic target. |
| format |
article |
| author |
Elena Sergeevna Kamyshova Irina Nikolaevna Bobkova Irina Mikhailovna Kutyrina |
| author_facet |
Elena Sergeevna Kamyshova Irina Nikolaevna Bobkova Irina Mikhailovna Kutyrina |
| author_sort |
Elena Sergeevna Kamyshova |
| title |
New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets |
| title_short |
New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets |
| title_full |
New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets |
| title_fullStr |
New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets |
| title_full_unstemmed |
New insights on microRNAs in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets |
| title_sort |
new insights on micrornas in diabetic nephropathy: potential biomarkers for diagnosis and therapeutic targets |
| publisher |
Endocrinology Research Centre |
| publishDate |
2017 |
| url |
https://doaj.org/article/fbf28cb2b829420d9af6687732f3627a |
| work_keys_str_mv |
AT elenasergeevnakamyshova newinsightsonmicrornasindiabeticnephropathypotentialbiomarkersfordiagnosisandtherapeutictargets AT irinanikolaevnabobkova newinsightsonmicrornasindiabeticnephropathypotentialbiomarkersfordiagnosisandtherapeutictargets AT irinamikhailovnakutyrina newinsightsonmicrornasindiabeticnephropathypotentialbiomarkersfordiagnosisandtherapeutictargets |
| _version_ |
1718429567053463552 |