Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants

Abstract Due to its unique properties, helium–oxygen (heliox) mixtures may provide benefits during non-invasive ventilation, however, knowledge regarding the effects of such therapy in premature infants is limited. This is the first report of heliox non-invasive neurally adjusted ventilatory assist...

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Autores principales:	Natalia Neumann-Klimasińska, T. Allen Merritt, Jennifer Beck, Izabela Miechowicz, Marta Szymankiewicz-Bręborowicz, Tomasz Szczapa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbf2a8f1aa4a42978fda3c2360e17d16
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spelling	oai:doaj.org-article:fbf2a8f1aa4a42978fda3c2360e17d162021-12-02T14:53:34ZEffects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants10.1038/s41598-021-95444-22045-2322https://doaj.org/article/fbf2a8f1aa4a42978fda3c2360e17d162021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95444-2https://doaj.org/toc/2045-2322Abstract Due to its unique properties, helium–oxygen (heliox) mixtures may provide benefits during non-invasive ventilation, however, knowledge regarding the effects of such therapy in premature infants is limited. This is the first report of heliox non-invasive neurally adjusted ventilatory assist (NIV-NAVA) ventilation applied in neonates born ≤ 32 weeks gestational age. After baseline NIV-NAVA ventilation with a standard mixture of air and oxygen, heliox was introduced for 3 h, followed by 3 h of air-oxygen. Heart rate, peripheral capillary oxygen saturation, cerebral oxygenation, electrical activity of the diaphragm (Edi) and selected ventilatory parameters (e.g., respiratory rate, peak inspiratory pressure) were continuously monitored. We found that application of heliox NIV-NAVA in preterm infants was feasible and associated with a prompt and significant decrease of Edi suggesting reduced respiratory effort, while all other parameters were stable throughout the study, and had similar values during heliox and air-oxygen ventilation. This therapy may potentially enhance the efficacy of non-invasive respiratory support in preterm neonates and reduce the number of infants progressing to ventilatory failure.Natalia Neumann-KlimasińskaT. Allen MerrittJennifer BeckIzabela MiechowiczMarta Szymankiewicz-BręborowiczTomasz SzczapaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalia Neumann-Klimasińska T. Allen Merritt Jennifer Beck Izabela Miechowicz Marta Szymankiewicz-Bręborowicz Tomasz Szczapa Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants
description	Abstract Due to its unique properties, helium–oxygen (heliox) mixtures may provide benefits during non-invasive ventilation, however, knowledge regarding the effects of such therapy in premature infants is limited. This is the first report of heliox non-invasive neurally adjusted ventilatory assist (NIV-NAVA) ventilation applied in neonates born ≤ 32 weeks gestational age. After baseline NIV-NAVA ventilation with a standard mixture of air and oxygen, heliox was introduced for 3 h, followed by 3 h of air-oxygen. Heart rate, peripheral capillary oxygen saturation, cerebral oxygenation, electrical activity of the diaphragm (Edi) and selected ventilatory parameters (e.g., respiratory rate, peak inspiratory pressure) were continuously monitored. We found that application of heliox NIV-NAVA in preterm infants was feasible and associated with a prompt and significant decrease of Edi suggesting reduced respiratory effort, while all other parameters were stable throughout the study, and had similar values during heliox and air-oxygen ventilation. This therapy may potentially enhance the efficacy of non-invasive respiratory support in preterm neonates and reduce the number of infants progressing to ventilatory failure.
format	article
author	Natalia Neumann-Klimasińska T. Allen Merritt Jennifer Beck Izabela Miechowicz Marta Szymankiewicz-Bręborowicz Tomasz Szczapa
author_facet	Natalia Neumann-Klimasińska T. Allen Merritt Jennifer Beck Izabela Miechowicz Marta Szymankiewicz-Bręborowicz Tomasz Szczapa
author_sort	Natalia Neumann-Klimasińska
title	Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants
title_short	Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants
title_full	Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants
title_fullStr	Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants
title_full_unstemmed	Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants
title_sort	effects of heliox and non-invasive neurally adjusted ventilatory assist (niv-nava) in preterm infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbf2a8f1aa4a42978fda3c2360e17d16
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Effects of heliox and non-invasive neurally adjusted ventilatory assist (NIV-NAVA) in preterm infants

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