Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of these antibodies as therapeutic inhibitors of arginase...

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Autores principales:	Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be6
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spelling	oai:doaj.org-article:fbf41ee3e220482a9ea5fcab675f2be62021-12-02T16:06:36ZCryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action10.1038/s42003-021-02444-z2399-3642https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be62021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02444-zhttps://doaj.org/toc/2399-3642Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of these antibodies as therapeutic inhibitors of arginasemediated T-cell suppression.Rachel L. PalteVeronica JuanYacob Gomez-LlorenteMarc Andre BaillyKalyan ChakravarthyXun ChenDaniel CiprianoLaurence Fayadat-DilmanSymon GathiakaHeiko GrebBrian HallMas HandaMark HsiehEsther KofmanHeping LinJ. Richard MillerNhung NguyenJennifer O’NeilHussam ShaheenEric SternerCorey StricklandAngie SunShane TaremiGiovanna ScapinNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Rachel L. Palte Veronica Juan Yacob Gomez-Llorente Marc Andre Bailly Kalyan Chakravarthy Xun Chen Daniel Cipriano Laurence Fayadat-Dilman Symon Gathiaka Heiko Greb Brian Hall Mas Handa Mark Hsieh Esther Kofman Heping Lin J. Richard Miller Nhung Nguyen Jennifer O’Neil Hussam Shaheen Eric Sterner Corey Strickland Angie Sun Shane Taremi Giovanna Scapin Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
description	Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of these antibodies as therapeutic inhibitors of arginasemediated T-cell suppression.
format	article
author	Rachel L. Palte Veronica Juan Yacob Gomez-Llorente Marc Andre Bailly Kalyan Chakravarthy Xun Chen Daniel Cipriano Laurence Fayadat-Dilman Symon Gathiaka Heiko Greb Brian Hall Mas Handa Mark Hsieh Esther Kofman Heping Lin J. Richard Miller Nhung Nguyen Jennifer O’Neil Hussam Shaheen Eric Sterner Corey Strickland Angie Sun Shane Taremi Giovanna Scapin
author_facet	Rachel L. Palte Veronica Juan Yacob Gomez-Llorente Marc Andre Bailly Kalyan Chakravarthy Xun Chen Daniel Cipriano Laurence Fayadat-Dilman Symon Gathiaka Heiko Greb Brian Hall Mas Handa Mark Hsieh Esther Kofman Heping Lin J. Richard Miller Nhung Nguyen Jennifer O’Neil Hussam Shaheen Eric Sterner Corey Strickland Angie Sun Shane Taremi Giovanna Scapin
author_sort	Rachel L. Palte
title	Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
title_short	Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
title_full	Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
title_fullStr	Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
title_full_unstemmed	Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
title_sort	cryo-em structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be6
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Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

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