Risk factors for rapid axial length elongation with low concentration atropine for myopia control

Abstract Three hundred and twenty-eight myopic children, randomized to use either 0.01% (N = 166) or 0.02% (N = 162) atropine were enrolled in this study. Gender, age, body mass index(BMI), parental myopia status, atropine concentration used, pupil diameter, amplitude of accommodation, spherical equ...

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Autores principales:	Aicun Fu, Fiona Stapleton, Li Wei, Weiqun Wang, Bingxin Zhao, Kathleen Watt, Shiao Yu, Can Cui, Yong Lyu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbf547cf5e2341789b359f2851742fac
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spelling	oai:doaj.org-article:fbf547cf5e2341789b359f2851742fac2021-12-02T15:03:13ZRisk factors for rapid axial length elongation with low concentration atropine for myopia control10.1038/s41598-021-88719-12045-2322https://doaj.org/article/fbf547cf5e2341789b359f2851742fac2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88719-1https://doaj.org/toc/2045-2322Abstract Three hundred and twenty-eight myopic children, randomized to use either 0.01% (N = 166) or 0.02% (N = 162) atropine were enrolled in this study. Gender, age, body mass index(BMI), parental myopia status, atropine concentration used, pupil diameter, amplitude of accommodation, spherical equivalent refractive error (SER), anterior chamber depth (ACD) and axial length (AL) were collected at baseline and 1 year after using atropine. Rapid AL elongation was defined as > 0.36 mm growth per year. Univariate analyses showed that children with rapid AL elongation tend to be younger, have a smaller BMI, use of 0.01% atropine, narrow ACD, lower SER, shorter AL, smaller change in pupil diameter between 1 year and baseline (all P < 0.05). Multivariate logistic regression analyses confirmed that rapid AL elongation was associated with children that were younger at baseline (P < 0.0001), use of 0.01% atropine (P = 0.04), a shorter baseline AL (P = 0.03) and a smaller change in pupil diameter between 1 year and baseline (P = 0.04). Younger children with shorter AL at baseline, less change in their pupil diameter with atropine treatment and using the lower of the two atropine concentrations may undergo rapid AL elongation over a 12 months myopia control treatment period.Aicun FuFiona StapletonLi WeiWeiqun WangBingxin ZhaoKathleen WattShiao YuCan CuiYong LyuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aicun Fu Fiona Stapleton Li Wei Weiqun Wang Bingxin Zhao Kathleen Watt Shiao Yu Can Cui Yong Lyu Risk factors for rapid axial length elongation with low concentration atropine for myopia control
description	Abstract Three hundred and twenty-eight myopic children, randomized to use either 0.01% (N = 166) or 0.02% (N = 162) atropine were enrolled in this study. Gender, age, body mass index(BMI), parental myopia status, atropine concentration used, pupil diameter, amplitude of accommodation, spherical equivalent refractive error (SER), anterior chamber depth (ACD) and axial length (AL) were collected at baseline and 1 year after using atropine. Rapid AL elongation was defined as > 0.36 mm growth per year. Univariate analyses showed that children with rapid AL elongation tend to be younger, have a smaller BMI, use of 0.01% atropine, narrow ACD, lower SER, shorter AL, smaller change in pupil diameter between 1 year and baseline (all P < 0.05). Multivariate logistic regression analyses confirmed that rapid AL elongation was associated with children that were younger at baseline (P < 0.0001), use of 0.01% atropine (P = 0.04), a shorter baseline AL (P = 0.03) and a smaller change in pupil diameter between 1 year and baseline (P = 0.04). Younger children with shorter AL at baseline, less change in their pupil diameter with atropine treatment and using the lower of the two atropine concentrations may undergo rapid AL elongation over a 12 months myopia control treatment period.
format	article
author	Aicun Fu Fiona Stapleton Li Wei Weiqun Wang Bingxin Zhao Kathleen Watt Shiao Yu Can Cui Yong Lyu
author_facet	Aicun Fu Fiona Stapleton Li Wei Weiqun Wang Bingxin Zhao Kathleen Watt Shiao Yu Can Cui Yong Lyu
author_sort	Aicun Fu
title	Risk factors for rapid axial length elongation with low concentration atropine for myopia control
title_short	Risk factors for rapid axial length elongation with low concentration atropine for myopia control
title_full	Risk factors for rapid axial length elongation with low concentration atropine for myopia control
title_fullStr	Risk factors for rapid axial length elongation with low concentration atropine for myopia control
title_full_unstemmed	Risk factors for rapid axial length elongation with low concentration atropine for myopia control
title_sort	risk factors for rapid axial length elongation with low concentration atropine for myopia control
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fbf547cf5e2341789b359f2851742fac
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Risk factors for rapid axial length elongation with low concentration atropine for myopia control

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