A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

The activation of drugs within cellular systems may provide targeted therapies for cancer. Here, the authors make a drug delivery system that is activated within the cell and exploits XIAP expression to cleave a linker region, resulting in the self-assembly of the system and drug release within canc...

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Autores principales: Hong-Wei An, Li-Li Li, Yi Wang, Ziqi Wang, Dayong Hou, Yao-Xin Lin, Sheng-Lin Qiao, Man-Di Wang, Chao Yang, Yong Cong, Yang Ma, Xiao-Xiao Zhao, Qian Cai, Wen-Ting Chen, Chu-Qi Lu, Wanhai Xu, Hao Wang, Yuliang Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/fbf5c28ff08842509d74e20473d50db1
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spelling oai:doaj.org-article:fbf5c28ff08842509d74e20473d50db12021-12-02T15:36:02ZA tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging10.1038/s41467-019-12848-52041-1723https://doaj.org/article/fbf5c28ff08842509d74e20473d50db12019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12848-5https://doaj.org/toc/2041-1723The activation of drugs within cellular systems may provide targeted therapies for cancer. Here, the authors make a drug delivery system that is activated within the cell and exploits XIAP expression to cleave a linker region, resulting in the self-assembly of the system and drug release within cancer cells.Hong-Wei AnLi-Li LiYi WangZiqi WangDayong HouYao-Xin LinSheng-Lin QiaoMan-Di WangChao YangYong CongYang MaXiao-Xiao ZhaoQian CaiWen-Ting ChenChu-Qi LuWanhai XuHao WangYuliang ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hong-Wei An
Li-Li Li
Yi Wang
Ziqi Wang
Dayong Hou
Yao-Xin Lin
Sheng-Lin Qiao
Man-Di Wang
Chao Yang
Yong Cong
Yang Ma
Xiao-Xiao Zhao
Qian Cai
Wen-Ting Chen
Chu-Qi Lu
Wanhai Xu
Hao Wang
Yuliang Zhao
A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
description The activation of drugs within cellular systems may provide targeted therapies for cancer. Here, the authors make a drug delivery system that is activated within the cell and exploits XIAP expression to cleave a linker region, resulting in the self-assembly of the system and drug release within cancer cells.
format article
author Hong-Wei An
Li-Li Li
Yi Wang
Ziqi Wang
Dayong Hou
Yao-Xin Lin
Sheng-Lin Qiao
Man-Di Wang
Chao Yang
Yong Cong
Yang Ma
Xiao-Xiao Zhao
Qian Cai
Wen-Ting Chen
Chu-Qi Lu
Wanhai Xu
Hao Wang
Yuliang Zhao
author_facet Hong-Wei An
Li-Li Li
Yi Wang
Ziqi Wang
Dayong Hou
Yao-Xin Lin
Sheng-Lin Qiao
Man-Di Wang
Chao Yang
Yong Cong
Yang Ma
Xiao-Xiao Zhao
Qian Cai
Wen-Ting Chen
Chu-Qi Lu
Wanhai Xu
Hao Wang
Yuliang Zhao
author_sort Hong-Wei An
title A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
title_short A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
title_full A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
title_fullStr A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
title_full_unstemmed A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
title_sort tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/fbf5c28ff08842509d74e20473d50db1
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