Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride

Background. Previously, we have shown that the polyhexamethylene guanidine hydrochloride hydrogel exhibits a pronounced wound healing. At the same time, no studies of the toxic effect of the hydrogel on animals have been conducted. Aim of the research. In the framework of this work, the acute toxici...

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Autores principales:	S. N. Lebedeva, O. S. Ochirov, M. N. Grigoryeva, S. D. Zhamsaranova, S. A. Stelmakh, D. M. Mognonov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2020
Materias:	polyhexamethylene guanidine hydrochloride hydrogel acute toxicity Science Q
Acceso en línea:	https://doaj.org/article/fbf94a8ff14f47b488e4d4858230ed46
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spelling	oai:doaj.org-article:fbf94a8ff14f47b488e4d4858230ed462021-11-23T06:14:44ZAcute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride2541-94202587-959610.29413/ABS.2020-5.4.15https://doaj.org/article/fbf94a8ff14f47b488e4d4858230ed462020-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2400https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Previously, we have shown that the polyhexamethylene guanidine hydrochloride hydrogel exhibits a pronounced wound healing. At the same time, no studies of the toxic effect of the hydrogel on animals have been conducted. Aim of the research. In the framework of this work, the acute toxicity of the hydrogel polyhexamethylene guanidine hydrochloride was studied in laboratory animals with intragastric administration. Materials and methods. The polyhexamethylene guanidine hydrochloride hydrogel was obtained by crosslinking the amino end groups with formaldehyde. An acute toxicity study was carried out (P 1.2.3156-13, GOST 32644-2014 and the Guidelines for conducting preclinical studies of drugs) in an experiment on outbred mice with a single addition of the test substance in different doses (1000, 3000, 5000, 8000 mg/kg) with fixing indicators (appearance, behavior, condition of the body hair coat, water and food consumption, excretion, body weight and its growth) during 14 days. After the animals were withdrawn from the experiment, autopsy, macroscopic evaluation and weighing of the internal organs were performed. The results showed that with the introduction of the test substance into the animal organism, death during the observation period (14 days) did not occur. It was not possible to determine the semi-lethal dose for the test compound. Conclusion. The conducted studies allow us to conclude that this substance is practically non-toxic and can be classified as hazard class V. Further research will be directed to the formation of hydrogel compositions with medicinal substances.S. N. LebedevaO. S. OchirovM. N. GrigoryevaS. D. ZhamsaranovaS. A. StelmakhD. M. MognonovScientific Сentre for Family Health and Human Reproduction Problemsarticlepolyhexamethylene guanidine hydrochloridehydrogelacute toxicityScienceQRUActa Biomedica Scientifica, Vol 5, Iss 4, Pp 103-107 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	polyhexamethylene guanidine hydrochloride hydrogel acute toxicity Science Q
spellingShingle	polyhexamethylene guanidine hydrochloride hydrogel acute toxicity Science Q S. N. Lebedeva O. S. Ochirov M. N. Grigoryeva S. D. Zhamsaranova S. A. Stelmakh D. M. Mognonov Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride
description	Background. Previously, we have shown that the polyhexamethylene guanidine hydrochloride hydrogel exhibits a pronounced wound healing. At the same time, no studies of the toxic effect of the hydrogel on animals have been conducted. Aim of the research. In the framework of this work, the acute toxicity of the hydrogel polyhexamethylene guanidine hydrochloride was studied in laboratory animals with intragastric administration. Materials and methods. The polyhexamethylene guanidine hydrochloride hydrogel was obtained by crosslinking the amino end groups with formaldehyde. An acute toxicity study was carried out (P 1.2.3156-13, GOST 32644-2014 and the Guidelines for conducting preclinical studies of drugs) in an experiment on outbred mice with a single addition of the test substance in different doses (1000, 3000, 5000, 8000 mg/kg) with fixing indicators (appearance, behavior, condition of the body hair coat, water and food consumption, excretion, body weight and its growth) during 14 days. After the animals were withdrawn from the experiment, autopsy, macroscopic evaluation and weighing of the internal organs were performed. The results showed that with the introduction of the test substance into the animal organism, death during the observation period (14 days) did not occur. It was not possible to determine the semi-lethal dose for the test compound. Conclusion. The conducted studies allow us to conclude that this substance is practically non-toxic and can be classified as hazard class V. Further research will be directed to the formation of hydrogel compositions with medicinal substances.
format	article
author	S. N. Lebedeva O. S. Ochirov M. N. Grigoryeva S. D. Zhamsaranova S. A. Stelmakh D. M. Mognonov
author_facet	S. N. Lebedeva O. S. Ochirov M. N. Grigoryeva S. D. Zhamsaranova S. A. Stelmakh D. M. Mognonov
author_sort	S. N. Lebedeva
title	Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride
title_short	Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride
title_full	Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride
title_fullStr	Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride
title_full_unstemmed	Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride
title_sort	acute toxicity of hydrogel polyhexamethylene guanidine hydrochloride
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2020
url	https://doaj.org/article/fbf94a8ff14f47b488e4d4858230ed46
work_keys_str_mv	AT snlebedeva acutetoxicityofhydrogelpolyhexamethyleneguanidinehydrochloride AT osochirov acutetoxicityofhydrogelpolyhexamethyleneguanidinehydrochloride AT mngrigoryeva acutetoxicityofhydrogelpolyhexamethyleneguanidinehydrochloride AT sdzhamsaranova acutetoxicityofhydrogelpolyhexamethyleneguanidinehydrochloride AT sastelmakh acutetoxicityofhydrogelpolyhexamethyleneguanidinehydrochloride AT dmmognonov acutetoxicityofhydrogelpolyhexamethyleneguanidinehydrochloride
_version_	1718416923071348736

Acute Toxicity of Hydrogel Polyhexamethylene Guanidine Hydrochloride

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