DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.

Most individuals successfully maintain psychological well-being even when exposed to trauma or adversity. Emotional resilience or the ability to thrive in the face of adversity is determined by complex interactions between genetic makeup, previous exposure to stress, personality, coping style, avail...

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Autores principales:	Debjani Das, Nicolas Cherbuin, Xiaoyun Tan, Kaarin J Anstey, Simon Easteal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fbfead582bbd4dceaf10d7bb2d853bd7
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spelling	oai:doaj.org-article:fbfead582bbd4dceaf10d7bb2d853bd72021-11-18T06:53:01ZDRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.1932-620310.1371/journal.pone.0020177https://doaj.org/article/fbfead582bbd4dceaf10d7bb2d853bd72011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21637770/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Most individuals successfully maintain psychological well-being even when exposed to trauma or adversity. Emotional resilience or the ability to thrive in the face of adversity is determined by complex interactions between genetic makeup, previous exposure to stress, personality, coping style, availability of social support, etc. Recent studies have demonstrated that childhood trauma diminishes resilience in adults and affects mental health. The Dopamine receptor D4 (DRD4) exon III variable number tandem repeat (VNTR) polymorphism was reported to moderate the impact of adverse childhood environment on behaviour, mood and other health-related outcomes. In this study we investigated whether DRD4-exIII-VNTR genotype moderates the effect of childhood adversities (CA) on resilience. In a representative population sample (n = 1148) aged 30-34 years, we observed an interactive effect of DRD4 genotype and CA (β = 0.132; p = 0.003) on resilience despite no main effect of the genotype when effects of age, gender and education were controlled for. The 7-repeat allele appears to protect against the adverse effect of CA since the decline in resilience associated with increased adversity was evident only in individuals without the 7-repeat allele. Resilience was also significantly associated with approach-/avoidance-related personality measures (behavioural inhibition/activation system; BIS/BAS) measures and an interactive effect of DRD4-exIII-VNTR genotype and CA on BAS was observed. Hence it is possible that approach-related personality traits could be mediating the effect of the DRD4 gene and childhood environment interaction on resilience such that when stressors are present, the 7-repeat allele influences the development of personality in a way that provides protection against adverse outcomes.Debjani DasNicolas CherbuinXiaoyun TanKaarin J AnsteySimon EastealPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20177 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Debjani Das Nicolas Cherbuin Xiaoyun Tan Kaarin J Anstey Simon Easteal DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.
description	Most individuals successfully maintain psychological well-being even when exposed to trauma or adversity. Emotional resilience or the ability to thrive in the face of adversity is determined by complex interactions between genetic makeup, previous exposure to stress, personality, coping style, availability of social support, etc. Recent studies have demonstrated that childhood trauma diminishes resilience in adults and affects mental health. The Dopamine receptor D4 (DRD4) exon III variable number tandem repeat (VNTR) polymorphism was reported to moderate the impact of adverse childhood environment on behaviour, mood and other health-related outcomes. In this study we investigated whether DRD4-exIII-VNTR genotype moderates the effect of childhood adversities (CA) on resilience. In a representative population sample (n = 1148) aged 30-34 years, we observed an interactive effect of DRD4 genotype and CA (β = 0.132; p = 0.003) on resilience despite no main effect of the genotype when effects of age, gender and education were controlled for. The 7-repeat allele appears to protect against the adverse effect of CA since the decline in resilience associated with increased adversity was evident only in individuals without the 7-repeat allele. Resilience was also significantly associated with approach-/avoidance-related personality measures (behavioural inhibition/activation system; BIS/BAS) measures and an interactive effect of DRD4-exIII-VNTR genotype and CA on BAS was observed. Hence it is possible that approach-related personality traits could be mediating the effect of the DRD4 gene and childhood environment interaction on resilience such that when stressors are present, the 7-repeat allele influences the development of personality in a way that provides protection against adverse outcomes.
format	article
author	Debjani Das Nicolas Cherbuin Xiaoyun Tan Kaarin J Anstey Simon Easteal
author_facet	Debjani Das Nicolas Cherbuin Xiaoyun Tan Kaarin J Anstey Simon Easteal
author_sort	Debjani Das
title	DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.
title_short	DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.
title_full	DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.
title_fullStr	DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.
title_full_unstemmed	DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.
title_sort	drd4-exoniii-vntr moderates the effect of childhood adversities on emotional resilience in young-adults.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/fbfead582bbd4dceaf10d7bb2d853bd7
work_keys_str_mv	AT debjanidas drd4exoniiivntrmoderatestheeffectofchildhoodadversitiesonemotionalresilienceinyoungadults AT nicolascherbuin drd4exoniiivntrmoderatestheeffectofchildhoodadversitiesonemotionalresilienceinyoungadults AT xiaoyuntan drd4exoniiivntrmoderatestheeffectofchildhoodadversitiesonemotionalresilienceinyoungadults AT kaarinjanstey drd4exoniiivntrmoderatestheeffectofchildhoodadversitiesonemotionalresilienceinyoungadults AT simoneasteal drd4exoniiivntrmoderatestheeffectofchildhoodadversitiesonemotionalresilienceinyoungadults
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DRD4-exonIII-VNTR moderates the effect of childhood adversities on emotional resilience in young-adults.

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