The Gut Microbiome and Individual-Specific Responses to Diet

ABSTRACT Nutritional content and timing are increasingly appreciated to constitute important human variables collectively impacting all aspects of human physiology and disease. However, person-specific mechanisms driving nutritional impacts on the human host remain incompletely understood, while cur...

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Autores principales:	Avner Leshem, Eran Segal, Eran Elinav
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	machine learning microbiome personalized nutrition Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/fbfff8ae133345f7ab0ad1ff2f398305
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spelling	oai:doaj.org-article:fbfff8ae133345f7ab0ad1ff2f3983052021-12-02T18:15:46ZThe Gut Microbiome and Individual-Specific Responses to Diet10.1128/mSystems.00665-202379-5077https://doaj.org/article/fbfff8ae133345f7ab0ad1ff2f3983052020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00665-20https://doaj.org/toc/2379-5077ABSTRACT Nutritional content and timing are increasingly appreciated to constitute important human variables collectively impacting all aspects of human physiology and disease. However, person-specific mechanisms driving nutritional impacts on the human host remain incompletely understood, while current dietary recommendations remain empirical and nonpersonalized. Precision nutrition aims to harness individualized bodies of data, including the human gut microbiome, in predicting person-specific physiological responses (such as glycemic responses) to food. With these advances notwithstanding, many unknowns remain, including the long-term efficacy of such interventions in delaying or reversing human metabolic disease, mechanisms driving these dietary effects, and the extent of the contribution of the gut microbiome to these processes. We summarize these conceptual advances, while highlighting challenges and means of addressing them in the next decade of study of precision medicine, toward generation of insights that may help to evolve precision nutrition as an effective future tool in a variety of “multifactorial” human disorders.Avner LeshemEran SegalEran ElinavAmerican Society for Microbiologyarticlemachine learningmicrobiomepersonalized nutritionMicrobiologyQR1-502ENmSystems, Vol 5, Iss 5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	machine learning microbiome personalized nutrition Microbiology QR1-502
spellingShingle	machine learning microbiome personalized nutrition Microbiology QR1-502 Avner Leshem Eran Segal Eran Elinav The Gut Microbiome and Individual-Specific Responses to Diet
description	ABSTRACT Nutritional content and timing are increasingly appreciated to constitute important human variables collectively impacting all aspects of human physiology and disease. However, person-specific mechanisms driving nutritional impacts on the human host remain incompletely understood, while current dietary recommendations remain empirical and nonpersonalized. Precision nutrition aims to harness individualized bodies of data, including the human gut microbiome, in predicting person-specific physiological responses (such as glycemic responses) to food. With these advances notwithstanding, many unknowns remain, including the long-term efficacy of such interventions in delaying or reversing human metabolic disease, mechanisms driving these dietary effects, and the extent of the contribution of the gut microbiome to these processes. We summarize these conceptual advances, while highlighting challenges and means of addressing them in the next decade of study of precision medicine, toward generation of insights that may help to evolve precision nutrition as an effective future tool in a variety of “multifactorial” human disorders.
format	article
author	Avner Leshem Eran Segal Eran Elinav
author_facet	Avner Leshem Eran Segal Eran Elinav
author_sort	Avner Leshem
title	The Gut Microbiome and Individual-Specific Responses to Diet
title_short	The Gut Microbiome and Individual-Specific Responses to Diet
title_full	The Gut Microbiome and Individual-Specific Responses to Diet
title_fullStr	The Gut Microbiome and Individual-Specific Responses to Diet
title_full_unstemmed	The Gut Microbiome and Individual-Specific Responses to Diet
title_sort	gut microbiome and individual-specific responses to diet
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/fbfff8ae133345f7ab0ad1ff2f398305
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The Gut Microbiome and Individual-Specific Responses to Diet

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