Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.

Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.

Mostrar otras versiones (1)

Capacitation is a complex maturation process mammalian sperm must undergo in the female genital tract to be able to fertilize an egg. This process involves, amongst others, physiological changes in flagellar beating pattern, membrane potential, intracellular ion concentrations and protein phosphoryl...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Alejandro Aguado-García, Daniel A Priego-Espinosa, Andrés Aldana, Alberto Darszon, Gustavo Martínez-Mekler
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fc03d2edba174df68fdb6d1b931d6909
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:fc03d2edba174df68fdb6d1b931d6909
record_format dspace
spelling oai:doaj.org-article:fc03d2edba174df68fdb6d1b931d69092021-12-02T20:12:52ZMathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.1932-620310.1371/journal.pone.0245816https://doaj.org/article/fc03d2edba174df68fdb6d1b931d69092021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0245816https://doaj.org/toc/1932-6203Capacitation is a complex maturation process mammalian sperm must undergo in the female genital tract to be able to fertilize an egg. This process involves, amongst others, physiological changes in flagellar beating pattern, membrane potential, intracellular ion concentrations and protein phosphorylation. Typically, in a capacitation medium, only a fraction of sperm achieve this state. The cause for this heterogeneous response is still not well understood and remains an open question. Here, one of our principal results is to develop a discrete regulatory network, with mostly deterministic dynamics in conjunction with some stochastic elements, for the main biochemical and biophysical processes involved in the early events of capacitation. The model criterion for capacitation requires the convergence of specific levels of a select set of nodes. Besides reproducing several experimental results and providing some insight on the network interrelations, the main contribution of the model is the suggestion that the degree of variability in the total amount and individual number of ion transporters among spermatozoa regulates the fraction of capacitated spermatozoa. This conclusion is consistent with recently reported experimental results. Based on this mathematical analysis, experimental clues are proposed for the control of capacitation levels. Furthermore, cooperative and interference traits that become apparent in the modelling among some components also call for future theoretical and experimental studies.Alejandro Aguado-GarcíaDaniel A Priego-EspinosaAndrés AldanaAlberto DarszonGustavo Martínez-MeklerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0245816 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alejandro Aguado-García
Daniel A Priego-Espinosa
Andrés Aldana
Alberto Darszon
Gustavo Martínez-Mekler
Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.
description Capacitation is a complex maturation process mammalian sperm must undergo in the female genital tract to be able to fertilize an egg. This process involves, amongst others, physiological changes in flagellar beating pattern, membrane potential, intracellular ion concentrations and protein phosphorylation. Typically, in a capacitation medium, only a fraction of sperm achieve this state. The cause for this heterogeneous response is still not well understood and remains an open question. Here, one of our principal results is to develop a discrete regulatory network, with mostly deterministic dynamics in conjunction with some stochastic elements, for the main biochemical and biophysical processes involved in the early events of capacitation. The model criterion for capacitation requires the convergence of specific levels of a select set of nodes. Besides reproducing several experimental results and providing some insight on the network interrelations, the main contribution of the model is the suggestion that the degree of variability in the total amount and individual number of ion transporters among spermatozoa regulates the fraction of capacitated spermatozoa. This conclusion is consistent with recently reported experimental results. Based on this mathematical analysis, experimental clues are proposed for the control of capacitation levels. Furthermore, cooperative and interference traits that become apparent in the modelling among some components also call for future theoretical and experimental studies.
format article
author Alejandro Aguado-García
Daniel A Priego-Espinosa
Andrés Aldana
Alberto Darszon
Gustavo Martínez-Mekler
author_facet Alejandro Aguado-García
Daniel A Priego-Espinosa
Andrés Aldana
Alberto Darszon
Gustavo Martínez-Mekler
author_sort Alejandro Aguado-García
title Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.
title_short Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.
title_full Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.
title_fullStr Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.
title_full_unstemmed Mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.
title_sort mathematical model reveals that heterogeneity in the number of ion transporters regulates the fraction of mouse sperm capacitation.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/fc03d2edba174df68fdb6d1b931d6909
work_keys_str_mv AT alejandroaguadogarcia mathematicalmodelrevealsthatheterogeneityinthenumberofiontransportersregulatesthefractionofmousespermcapacitation
AT danielapriegoespinosa mathematicalmodelrevealsthatheterogeneityinthenumberofiontransportersregulatesthefractionofmousespermcapacitation
AT andresaldana mathematicalmodelrevealsthatheterogeneityinthenumberofiontransportersregulatesthefractionofmousespermcapacitation
AT albertodarszon mathematicalmodelrevealsthatheterogeneityinthenumberofiontransportersregulatesthefractionofmousespermcapacitation
AT gustavomartinezmekler mathematicalmodelrevealsthatheterogeneityinthenumberofiontransportersregulatesthefractionofmousespermcapacitation
_version_ 1718374862243758080

Ejemplares similares