Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling

The increasing incidence of stress-induced cardiomyopathy is due to the complexities of our modern-day lives, which constantly elicit stress responses. Herein, we aimed to explore the therapeutic potential of Amlexanox and Forskolin in promoting the recovery from stress-induced cardiomyopathy. Isopr...

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Autores principales:	Gabriel Komla Adzika, Hongjian Hou, Adebayo Oluwafemi Adekunle, Ruqayya Rizvi, Joseph Adu-Amankwaah, Wenkang Shang, Kexue Li, Qi-Ming Deng, Richard Mprah, Marie Louise Ndzie Noah, Hong Sun
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	stress amlexanox forskolin isoproterenol-induced cardiomyopathy left ventricular systolic dysfunction myocardial inflammation Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/fc0525dab0d74607b350a97148750e1b
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spelling	oai:doaj.org-article:fc0525dab0d74607b350a97148750e1b2021-11-30T22:57:01ZIsoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling2297-055X10.3389/fcvm.2021.719805https://doaj.org/article/fc0525dab0d74607b350a97148750e1b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.719805/fullhttps://doaj.org/toc/2297-055XThe increasing incidence of stress-induced cardiomyopathy is due to the complexities of our modern-day lives, which constantly elicit stress responses. Herein, we aimed to explore the therapeutic potential of Amlexanox and Forskolin in promoting the recovery from stress-induced cardiomyopathy. Isoproterenol-induced cardiomyopathy (ICM) models were made, and the following treatment interventions were administered: 5% v/v DMSO as a placebo, Amlexanox (2.5 mg/100 g/day) treatment, Forskolin (0.5 mg/100 g/day), and Amlexanox and Forskolin combination, at their respective aforementioned dosages. The effects of Amlexanox and Forskolin treatment on ICM models were assessed by eletrocardiography and echocardiography. Also, using histological analysis and ELISA, their impact on myocardial architecture and inflammation were ascertained. ICM mice had excessive myocardial fibrosis, hypertrophy, and aggravated LVSDs which were accompanied by massive CD86+ inflammatory cells infiltration. Amlexanox treatment attenuated the myocardial hypertrophy, fibrosis, and inflammation and also slightly improved systolic functions. Meanwhile, forskolin treatment resulted in arrhythmias but significantly enhanced the resolution of myocardial fibrosis and inflammation. Intriguingly, Amlexanox and Forskolin combination demonstrated the most potency at promoting the recovery of the ICM from LVSD by attenuating maladaptive myocardial hypertrophy, fibrosis, and inflammatory responses. Our findings highlight the Amlexanox and Forskolin combination as a potential therapeutic intervention for enhancing cardiac function recovery from stress-induced cardiomyopathy by promoting the resolution of maladaptive cardiac remodeling.Gabriel Komla AdzikaHongjian HouHongjian HouAdebayo Oluwafemi AdekunleRuqayya RizviJoseph Adu-AmankwaahWenkang ShangWenkang ShangKexue LiQi-Ming DengRichard MprahMarie Louise Ndzie NoahHong SunFrontiers Media S.A.articlestressamlexanoxforskolinisoproterenol-induced cardiomyopathyleft ventricular systolic dysfunctionmyocardial inflammationDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stress amlexanox forskolin isoproterenol-induced cardiomyopathy left ventricular systolic dysfunction myocardial inflammation Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	stress amlexanox forskolin isoproterenol-induced cardiomyopathy left ventricular systolic dysfunction myocardial inflammation Diseases of the circulatory (Cardiovascular) system RC666-701 Gabriel Komla Adzika Hongjian Hou Hongjian Hou Adebayo Oluwafemi Adekunle Ruqayya Rizvi Joseph Adu-Amankwaah Wenkang Shang Wenkang Shang Kexue Li Qi-Ming Deng Richard Mprah Marie Louise Ndzie Noah Hong Sun Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling
description	The increasing incidence of stress-induced cardiomyopathy is due to the complexities of our modern-day lives, which constantly elicit stress responses. Herein, we aimed to explore the therapeutic potential of Amlexanox and Forskolin in promoting the recovery from stress-induced cardiomyopathy. Isoproterenol-induced cardiomyopathy (ICM) models were made, and the following treatment interventions were administered: 5% v/v DMSO as a placebo, Amlexanox (2.5 mg/100 g/day) treatment, Forskolin (0.5 mg/100 g/day), and Amlexanox and Forskolin combination, at their respective aforementioned dosages. The effects of Amlexanox and Forskolin treatment on ICM models were assessed by eletrocardiography and echocardiography. Also, using histological analysis and ELISA, their impact on myocardial architecture and inflammation were ascertained. ICM mice had excessive myocardial fibrosis, hypertrophy, and aggravated LVSDs which were accompanied by massive CD86+ inflammatory cells infiltration. Amlexanox treatment attenuated the myocardial hypertrophy, fibrosis, and inflammation and also slightly improved systolic functions. Meanwhile, forskolin treatment resulted in arrhythmias but significantly enhanced the resolution of myocardial fibrosis and inflammation. Intriguingly, Amlexanox and Forskolin combination demonstrated the most potency at promoting the recovery of the ICM from LVSD by attenuating maladaptive myocardial hypertrophy, fibrosis, and inflammatory responses. Our findings highlight the Amlexanox and Forskolin combination as a potential therapeutic intervention for enhancing cardiac function recovery from stress-induced cardiomyopathy by promoting the resolution of maladaptive cardiac remodeling.
format	article
author	Gabriel Komla Adzika Hongjian Hou Hongjian Hou Adebayo Oluwafemi Adekunle Ruqayya Rizvi Joseph Adu-Amankwaah Wenkang Shang Wenkang Shang Kexue Li Qi-Ming Deng Richard Mprah Marie Louise Ndzie Noah Hong Sun
author_facet	Gabriel Komla Adzika Hongjian Hou Hongjian Hou Adebayo Oluwafemi Adekunle Ruqayya Rizvi Joseph Adu-Amankwaah Wenkang Shang Wenkang Shang Kexue Li Qi-Ming Deng Richard Mprah Marie Louise Ndzie Noah Hong Sun
author_sort	Gabriel Komla Adzika
title	Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling
title_short	Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling
title_full	Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling
title_fullStr	Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling
title_full_unstemmed	Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling
title_sort	isoproterenol-induced cardiomyopathy recovery intervention: amlexanox and forskolin enhances the resolution of catecholamine stress-induced maladaptive myocardial remodeling
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fc0525dab0d74607b350a97148750e1b
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Isoproterenol-Induced Cardiomyopathy Recovery Intervention: Amlexanox and Forskolin Enhances the Resolution of Catecholamine Stress-Induced Maladaptive Myocardial Remodeling

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