Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome

Patrick Walden, Qingmei Jiang, Elizabeth A Jackson, Elif A Oral, Martha S Weintraub, Melvyn Rubenfire Division of Cardiovascular Medicine, Cardiovascular Medicine at Domino’s Farms, University of Michigan Health System, Ann Arbor, MI, USA Background: Lifestyle interventions targeting the...

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Autores principales:	Walden P, Jiang Q, Jackson EA, Oral EA, Weintraub MS, Rubenfire M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	lifestyle intervention metabolic syndrome diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/fc06a6e7c4804330a95fff37c9ae3d0b
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spelling	oai:doaj.org-article:fc06a6e7c4804330a95fff37c9ae3d0b2021-12-02T02:46:55ZAssessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome1178-7007https://doaj.org/article/fc06a6e7c4804330a95fff37c9ae3d0b2016-06-01T00:00:00Zhttps://www.dovepress.com/assessing-the-incremental-benefit-of-an-extended-duration-lifestyle-in-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Patrick Walden, Qingmei Jiang, Elizabeth A Jackson, Elif A Oral, Martha S Weintraub, Melvyn Rubenfire Division of Cardiovascular Medicine, Cardiovascular Medicine at Domino’s Farms, University of Michigan Health System, Ann Arbor, MI, USA Background: Lifestyle interventions targeting the components of the metabolic syndrome (MetSyn) have been demonstrated to be a cost-effective and suitable treatment strategy for reducing one’s risk of developing coronary artery disease and diabetes. The optimal duration has not yet been defined. We sought to evaluate the incremental benefit of extending a lifestyle intervention from 3 months to 6 months. Methods: We evaluated 114 participants with at least three criteria for the MetSyn in a physician-referred 6-month lifestyle intervention between August 2008 and December 2012. Baseline and follow-up physiological, biochemical, and anthropometric data were analyzed for mean change and incremental change at each time point. Results: The mean age at enrollment was 53.0±10.2 years, and 42% of participants were males. The mean body mass index at enrollment was 38.2±0.86 kg/m2 for males and 38.6±0.93 kg/m2 for females. Anthropometric measures associated with weight management (body mass index, weight, and body fat percentage) improved significantly with the additional 3-month intervention (P<0.001). Systolic blood pressure (P=0.0001) and diastolic blood pressure (P=0.00006) and triglycerides, fasting blood glucose, and homeostatic model assessment of insulin resistance in diabetic participants (P=0.006, P=0.004, P=0.01, respectively) improved rapidly in the initial 3-month intervention without incremental benefit of the additional 3 months. Improvements in fasting insulin (P=0.01) and homeostatic model assessment of insulin resistance (P=0.02) for nondiabetic participants required the full 6-month intervention before significant reductions were achieved. Conclusion: A 6-month lifestyle intervention yielded significantly better results for variables related to weight management. Standard physiological measures for the MetSyn respond rapidly in a 3-month lifestyle intervention. The long-term impact of an increased duration lifestyle intervention remains to be seen. Keywords: lifestyle intervention, metabolic syndrome, diabetesWalden PJiang QJackson EAOral EAWeintraub MSRubenfire MDove Medical Pressarticlelifestyle interventionmetabolic syndromediabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 177-184 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	lifestyle intervention metabolic syndrome diabetes Specialties of internal medicine RC581-951
spellingShingle	lifestyle intervention metabolic syndrome diabetes Specialties of internal medicine RC581-951 Walden P Jiang Q Jackson EA Oral EA Weintraub MS Rubenfire M Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome
description	Patrick Walden, Qingmei Jiang, Elizabeth A Jackson, Elif A Oral, Martha S Weintraub, Melvyn Rubenfire Division of Cardiovascular Medicine, Cardiovascular Medicine at Domino’s Farms, University of Michigan Health System, Ann Arbor, MI, USA Background: Lifestyle interventions targeting the components of the metabolic syndrome (MetSyn) have been demonstrated to be a cost-effective and suitable treatment strategy for reducing one’s risk of developing coronary artery disease and diabetes. The optimal duration has not yet been defined. We sought to evaluate the incremental benefit of extending a lifestyle intervention from 3 months to 6 months. Methods: We evaluated 114 participants with at least three criteria for the MetSyn in a physician-referred 6-month lifestyle intervention between August 2008 and December 2012. Baseline and follow-up physiological, biochemical, and anthropometric data were analyzed for mean change and incremental change at each time point. Results: The mean age at enrollment was 53.0±10.2 years, and 42% of participants were males. The mean body mass index at enrollment was 38.2±0.86 kg/m2 for males and 38.6±0.93 kg/m2 for females. Anthropometric measures associated with weight management (body mass index, weight, and body fat percentage) improved significantly with the additional 3-month intervention (P<0.001). Systolic blood pressure (P=0.0001) and diastolic blood pressure (P=0.00006) and triglycerides, fasting blood glucose, and homeostatic model assessment of insulin resistance in diabetic participants (P=0.006, P=0.004, P=0.01, respectively) improved rapidly in the initial 3-month intervention without incremental benefit of the additional 3 months. Improvements in fasting insulin (P=0.01) and homeostatic model assessment of insulin resistance (P=0.02) for nondiabetic participants required the full 6-month intervention before significant reductions were achieved. Conclusion: A 6-month lifestyle intervention yielded significantly better results for variables related to weight management. Standard physiological measures for the MetSyn respond rapidly in a 3-month lifestyle intervention. The long-term impact of an increased duration lifestyle intervention remains to be seen. Keywords: lifestyle intervention, metabolic syndrome, diabetes
format	article
author	Walden P Jiang Q Jackson EA Oral EA Weintraub MS Rubenfire M
author_facet	Walden P Jiang Q Jackson EA Oral EA Weintraub MS Rubenfire M
author_sort	Walden P
title	Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome
title_short	Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome
title_full	Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome
title_fullStr	Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome
title_full_unstemmed	Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome
title_sort	assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/fc06a6e7c4804330a95fff37c9ae3d0b
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Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome

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