Induction of trained immunity by influenza vaccination - impact on COVID-19.
Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained immunity, has been proposed as one of the mechanisms mediating these effects. Several epidemiological studies suggested cross-protection between influenza vaccination and...
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Public Library of Science (PLoS)
2021
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oai:doaj.org-article:fc082979274c412fbfb54b69a2f5e96c2021-12-02T19:59:42ZInduction of trained immunity by influenza vaccination - impact on COVID-19.1553-73661553-737410.1371/journal.ppat.1009928https://doaj.org/article/fc082979274c412fbfb54b69a2f5e96c2021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009928https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained immunity, has been proposed as one of the mechanisms mediating these effects. Several epidemiological studies suggested cross-protection between influenza vaccination and COVID-19. In a large academic Dutch hospital, we found that SARS-CoV-2 infection was less common among employees who had received a previous influenza vaccination: relative risk reductions of 37% and 49% were observed following influenza vaccination during the first and second COVID-19 waves, respectively. The quadrivalent inactivated influenza vaccine induced a trained immunity program that boosted innate immune responses against various viral stimuli and fine-tuned the anti-SARS-CoV-2 response, which may result in better protection against COVID-19. Influenza vaccination led to transcriptional reprogramming of monocytes and reduced systemic inflammation. These epidemiological and immunological data argue for potential benefits of influenza vaccination against COVID-19, and future randomized trials are warranted to test this possibility.Priya A DebisarunKatharina L GösslingOzlem BulutGizem KilicMartijn ZoodsmaZhaoli LiuMarina OldenburgNadine RüchelBowen ZhangCheng-Jian XuPatrick StruyckenValerie A C M KoekenJorge Domínguez-AndrésSimone J C F M MoorlagEsther TaksPhilipp N OstermannLisa MüllerHeiner SchaalOrtwin AdamsArndt BorkhardtJaap Ten OeverReinout van CrevelYang LiMihai G NeteaPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 10, p e1009928 (2021) |
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Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
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Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Priya A Debisarun Katharina L Gössling Ozlem Bulut Gizem Kilic Martijn Zoodsma Zhaoli Liu Marina Oldenburg Nadine Rüchel Bowen Zhang Cheng-Jian Xu Patrick Struycken Valerie A C M Koeken Jorge Domínguez-Andrés Simone J C F M Moorlag Esther Taks Philipp N Ostermann Lisa Müller Heiner Schaal Ortwin Adams Arndt Borkhardt Jaap Ten Oever Reinout van Crevel Yang Li Mihai G Netea Induction of trained immunity by influenza vaccination - impact on COVID-19. |
| description |
Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained immunity, has been proposed as one of the mechanisms mediating these effects. Several epidemiological studies suggested cross-protection between influenza vaccination and COVID-19. In a large academic Dutch hospital, we found that SARS-CoV-2 infection was less common among employees who had received a previous influenza vaccination: relative risk reductions of 37% and 49% were observed following influenza vaccination during the first and second COVID-19 waves, respectively. The quadrivalent inactivated influenza vaccine induced a trained immunity program that boosted innate immune responses against various viral stimuli and fine-tuned the anti-SARS-CoV-2 response, which may result in better protection against COVID-19. Influenza vaccination led to transcriptional reprogramming of monocytes and reduced systemic inflammation. These epidemiological and immunological data argue for potential benefits of influenza vaccination against COVID-19, and future randomized trials are warranted to test this possibility. |
| format |
article |
| author |
Priya A Debisarun Katharina L Gössling Ozlem Bulut Gizem Kilic Martijn Zoodsma Zhaoli Liu Marina Oldenburg Nadine Rüchel Bowen Zhang Cheng-Jian Xu Patrick Struycken Valerie A C M Koeken Jorge Domínguez-Andrés Simone J C F M Moorlag Esther Taks Philipp N Ostermann Lisa Müller Heiner Schaal Ortwin Adams Arndt Borkhardt Jaap Ten Oever Reinout van Crevel Yang Li Mihai G Netea |
| author_facet |
Priya A Debisarun Katharina L Gössling Ozlem Bulut Gizem Kilic Martijn Zoodsma Zhaoli Liu Marina Oldenburg Nadine Rüchel Bowen Zhang Cheng-Jian Xu Patrick Struycken Valerie A C M Koeken Jorge Domínguez-Andrés Simone J C F M Moorlag Esther Taks Philipp N Ostermann Lisa Müller Heiner Schaal Ortwin Adams Arndt Borkhardt Jaap Ten Oever Reinout van Crevel Yang Li Mihai G Netea |
| author_sort |
Priya A Debisarun |
| title |
Induction of trained immunity by influenza vaccination - impact on COVID-19. |
| title_short |
Induction of trained immunity by influenza vaccination - impact on COVID-19. |
| title_full |
Induction of trained immunity by influenza vaccination - impact on COVID-19. |
| title_fullStr |
Induction of trained immunity by influenza vaccination - impact on COVID-19. |
| title_full_unstemmed |
Induction of trained immunity by influenza vaccination - impact on COVID-19. |
| title_sort |
induction of trained immunity by influenza vaccination - impact on covid-19. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/fc082979274c412fbfb54b69a2f5e96c |
| work_keys_str_mv |
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